ArticleMolecular pharmacology2020
Discovery of Small Molecules That Target the Phosphatidylinositol (3,4,5) Trisphosphate (PIP
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Article in Molecular pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Article
- GEF me a break: the consequences of freezing Rho guanine-nucleotide exchange factor catalytic domains.bioRxiv : the preprint server for biology · 2026Article
- An active allosteric mechanism in ASAP1-mediated Arf1 GTP hydrolysis redefines PH domain function.Nature communications · 2025Article
- PI(3,4,5)P3-mediated Cdc42 activation regulates macrophage podosome assembly.Cellular and molecular life sciences : CMLS · 2025Article
- The PH domain in the ArfGAP ASAP1 drives catalytic activation through an unprecedented allosteric mechanism.bioRxiv : the preprint server for biology · 2024Article
- Understanding P-Rex regulation: structural breakthroughs and emerging perspectives.Biochemical Society transactions · 2024Review
- New Mechanisms Underlying Oncogenesis in Dbl Family Rho Guanine Nucleotide Exchange Factors.Molecular pharmacology · 2024Review
- Migration, invasion, and metastasis are mediated byFrontiers in oncology · 2024Article
- The pseudokinase NRBP1 activates Rac1/Cdc42 via P-Rex1 to drive oncogenic signalling in triple-negative breast cancer.Oncogene · 2023Article
- Structural Dynamics of P-Rex1 Complexed with Natural Leads Establishes the Protein as an Attractive Target for Therapeutics to Suppress Cancer Metastasis.BioMed research international · 2023Article
- Systematic simulation of the interactions of pleckstrin homology domains with membranes.Science advances · 2022Article
- A network of GαScience signaling · 2022Article
- Small-molecule inhibitors of P-Rex guanine-nucleotide exchange factors.Small GTPases · 2022Article
- P-Rex1 Cooperates With TGFβR2 to Drive Lung Fibroblast Migration in Pulmonary Fibrosis.Frontiers in pharmacology · 2021Article
- Inositol Polyphosphate-Based Compounds as Inhibitors of Phosphoinositide 3-Kinase-Dependent Signaling.International journal of molecular sciences · 2020Review
- Identification of P-Rex1 in the Regulation of Liver Cancer Cell Proliferation and Migration via HGF/c-Met/Akt Pathway.OncoTargets and therapy · 2020Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Jennifer N CashDepartments of Pharmacology and Biological Chemistry, Life Sciences Institute, University of Michigan, Ann Arbor, Michigan (J.N.C., P.V.S.); Department of Pharmacology, University of Michigan, Ann Arbor, Michigan (N.R.C., A.V.S.); and Departments of Biological Sciences (A.Y.H., Q.D., J.J.G.T.) and Medicinal Chemistry and Molecular Pharmacology (J.J.G.T.), Purdue University, West Lafayette, Indiana.ORCID 0000-0002-0277-7652
Naincy R ChandanDepartments of Pharmacology and Biological Chemistry, Life Sciences Institute, University of Michigan, Ann Arbor, Michigan (J.N.C., P.V.S.); Department of Pharmacology, University of Michigan, Ann Arbor, Michigan (N.R.C., A.V.S.); and Departments of Biological Sciences (A.Y.H., Q.D., J.J.G.T.) and Medicinal Chemistry and Molecular Pharmacology (J.J.G.T.), Purdue University, West Lafayette, Indiana.
Alan Y HsuDepartments of Pharmacology and Biological Chemistry, Life Sciences Institute, University of Michigan, Ann Arbor, Michigan (J.N.C., P.V.S.); Department of Pharmacology, University of Michigan, Ann Arbor, Michigan (N.R.C., A.V.S.); and Departments of Biological Sciences (A.Y.H., Q.D., J.J.G.T.) and Medicinal Chemistry and Molecular Pharmacology (J.J.G.T.), Purdue University, West Lafayette, Indiana.ORCID 0000-0001-5680-345X
Prateek V SharmaDepartments of Pharmacology and Biological Chemistry, Life Sciences Institute, University of Michigan, Ann Arbor, Michigan (J.N.C., P.V.S.); Department of Pharmacology, University of Michigan, Ann Arbor, Michigan (N.R.C., A.V.S.); and Departments of Biological Sciences (A.Y.H., Q.D., J.J.G.T.) and Medicinal Chemistry and Molecular Pharmacology (J.J.G.T.), Purdue University, West Lafayette, Indiana.
Qing DengDepartments of Pharmacology and Biological Chemistry, Life Sciences Institute, University of Michigan, Ann Arbor, Michigan (J.N.C., P.V.S.); Department of Pharmacology, University of Michigan, Ann Arbor, Michigan (N.R.C., A.V.S.); and Departments of Biological Sciences (A.Y.H., Q.D., J.J.G.T.) and Medicinal Chemistry and Molecular Pharmacology (J.J.G.T.), Purdue University, West Lafayette, Indiana.ORCID 0000-0002-9254-9951
Alan V SmrckaDepartments of Pharmacology and Biological Chemistry, Life Sciences Institute, University of Michigan, Ann Arbor, Michigan (J.N.C., P.V.S.); Department of Pharmacology, University of Michigan, Ann Arbor, Michigan (N.R.C., A.V.S.); and Departments of Biological Sciences (A.Y.H., Q.D., J.J.G.T.) and Medicinal Chemistry and Molecular Pharmacology (J.J.G.T.), Purdue University, West Lafayette, Indiana.
John J G TesmerDepartments of Pharmacology and Biological Chemistry, Life Sciences Institute, University of Michigan, Ann Arbor, Michigan (J.N.C., P.V.S.); Department of Pharmacology, University of Michigan, Ann Arbor, Michigan (N.R.C., A.V.S.); and Departments of Biological Sciences (A.Y.H., Q.D., J.J.G.T.) and Medicinal Chemistry and Molecular Pharmacology (J.J.G.T.), Purdue University, West Lafayette, Indiana jtesmer@purdue.edu.ORCID 0000-0003-1125-3727
Purdue University West Lafayette · US
Funding
Structure, function, and inhibition of G protein-coupled receptor kinasesR01HL071818 · NHLBI · UNIVERSITY OF TEXAS AUSTIN · PI TESMER, JOHN · 2004 to 2023
$7.1MRole of microRNAs in neutrophil migrationR35GM119787 · NIGMS · PURDUE UNIVERSITY · PI Qing Deng · 2016 to 2026
$4.9MUnderstanding and Manipulating Phospholipase C and G Protein beta gamma subunit Signaling NetworksR35GM127303 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alan V. Smrcka · 2018 to 2026
$4.8MStructure and Function of the LPLA2/LCAT Acyltransferase FamilyR01HL122416 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TESMER, JOHN · 2015 to 2018
$1.9MGPCR - Linked RhoGEFs in Tumor Growth and MetastasisR01CA221289 · NCI · PURDUE UNIVERSITY · PI TESMER, JOHN · 2018 to 2022
$1.9MNCI NIH HHS R01 CA221289NHLBI NIH HHS R01 HL071818NHLBI NIH HHS R01 HL122416NIGMS NIH HHS R35 GM119787NIGMS NIH HHS R35 GM127303
Abstract
Phosphatidylinositol (3,4,5) trisphosphate (PIP
Indexed as
AnimalsBinding SitesCells, CulturedCrystallography, X-RayDose-Response Relationship, DrugDrug Delivery SystemsDrug DiscoveryGuanine Nucleotide Exchange FactorsHumansNeutrophilsPhosphatidylinositol PhosphatesProtein Structure, SecondaryProtein Structure, TertiaryZebrafishGuanine Nucleotide Exchange Factorsphosphatidylinositol 3,4,5-triphosphatePhosphatidylinositol PhosphatesPREX1 protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.