ArticleJournal of biomedical science2020
Detection and phylogeny of Staphylococcus aureus sequence type 398 in Taiwan.
Article in Journal of biomedical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- Evolutionary and Mobile Genetic Element Analysis of a Multidrug-Resistant ST398-MRSA-Vc Isolate from Ready-to-Eat Pork Products.Antibiotics (Basel, Switzerland) · 2026Article
- Genomic and phylogenetic characterization of human-adapted methicillin-resistantMicrobiology spectrum · 2026Article
- The alert for emergence of pig-associated MRSA ST 398 in multi-regions China.One health (Amsterdam, Netherlands) · 2025Article
- Prevalence and Characterization ofMicroorganisms · 2025Article
- The Role of Prophage ϕSa3 in the Adaption ofAntibiotics (Basel, Switzerland) · 2024Article
- Comparing the Phylogenetic Distribution of Multilocus Sequence Typing, Staphylococcal Protein A, and Staphylococcal Cassette Chromosome Mec Types in Methicillin-Resistant Staphylococcus Aureus (MRSA) in Korea from 1994 to 2020.Antibiotics (Basel, Switzerland) · 2023Article
- The Epidemiology of Animal-Associated Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2023Review
- Prevalence and Virulence Determinants ofFoods (Basel, Switzerland) · 2022Article
- Investigating Unfavorable Factors That Impede MALDI-TOF-Based AI in Predicting Antibiotic Resistance.Diagnostics (Basel, Switzerland) · 2022Article
- Article
- Antimicrobial Resistance and Molecular Characterization of Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2021Article
- Whole-Genome Epidemiology and Characterization of Methicillin-SusceptibleFrontiers in microbiology · 2021Article
- The Surge of Hypervirulent ST398 MRSA Lineage With Higher Biofilm-Forming Ability Is a Critical Threat to Clinics.Frontiers in microbiology · 2021Article
- Human Infection of Methicillin-SusceptibleMicroorganisms · 2020Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundMethicillin-resistant Staphylococcus aureus (MRSA) ST398 is a livestock associated-bacterium that is most prevalent in Europe. Human-adapted MRSA ST398 was recently reported from China, but there is no data available yet for Taiwan.
methodsTo identify S. aureus ST398 isolates, we examined 6413 S. aureus isolates (5632 MRSA and 781 susceptible strains) that were collected in Taiwan between 1995 and 2017. If isolates could not be typed by pulsed-field gel electrophoresis upon Sma I digestion, we performed further characterization and complete genome sequencing.
resultsWe identified 18 ST398 S. aureus isolates from 16 subjects (0.28%), including 6 sensitive and 12 resistant strains. Of these, 14 were colonizing isolates, 3 were clinical (infecting) isolates and one isolate was from a pork specimen. All 3 infecting isolates were MSSA strains identified in 2015 from two children with recurrent otitis media or sinusitis. The other 3 MSSA isolates were identified from workers handling pork (2) or pork meat (1) in 2015. The first 5 MRSA colonizing isolates were identified from residents in two nursing homes in 2012. Six MRSA isolates were identified from residents and foreign employees at a nursing home in 2016 and one MRSA from a foreign worker in 2017. Phylogenetic analysis of genome sequences indicated that all 12 local ST398 MRSA strains cluster together, human-adapted and phylogenetically related to a human MRSA strain identified in China in 2002. Two local MSSA isolates could be linked to isolates from livestock. The toxin profiles were similar for the MRSA and MSSA isolates.
conclusionsOur results demonstrate that S. aureus ST398 was present in Taiwan in 2012 and potentially earlier. Although some isolates could be linked to livestock, most ST398 S. aureus isolates identified in Taiwan, particularly MRSA, represent human-adapted strains. Local transmission of human-adapted MRSA ST398 strains has occurred in nursing homes in Taiwan, possibly after import from China. Further surveillance is needed.
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