Trial reportJournal of translational medicine2019
Risk factors influencing survival of acellular porcine corneal stroma in infectious keratitis: a prospective clinical study.
Trial report in Journal of translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03105466 (Prospective Study of Deep Anterior Lamellar Keratoplasty Using Acellular Porcine Cornea), which is not on this map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prospective Study of Deep Anterior Lamellar Keratoplasty Using Acellular Porcine Cornea
Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Machine learning approaches for predicting and diagnosing chronic kidney disease: current trends, challenges, solutions, and future directions.International urology and nephrology · 2025Review
- Bio-orthogonal crosslinking and hyaluronan facilitate transparent healing after treatment of deep corneal injuries with in situ-forming hydrogels.NPJ Regenerative medicine · 2025Article
- Preparation, physico-biochemical characterization, and proteomic analysis of highly transparent corneal extracellular matrices for lamellar keratoplasty and tissue-engineered cornea construction.Materials today. Bio · 2024Article
- Herpes simplex keratitis: A brief clinical overview.World journal of virology · 2024Review
- A surgical alternative of fusiform penetrating keratoplasty for the management of severe infectious keratitis.International journal of ophthalmology · 2024Article
- Small-diameter acellular porcine corneal stroma for peripheral corneal ulceration treatment.International journal of ophthalmology · 2024Article
- Chemical, Physical, and Biological Corneal Decellularization Methods: A Review of Literature.Journal of ophthalmology · 2024Review
- Preclinical evaluation of the safety and effectiveness of a new bioartificial cornea.Bioactive materials · 2023Article
- In Situ-Forming Collagen-Hyaluronate Semi-Interpenetrating Network Hydrogel Enhances Corneal Defect Repair.Translational vision science & technology · 2022Article
- Lamellar Keratoplasty Using Acellular Bioengineering Cornea (BioCorneaVetAnimals : an open access journal from MDPI · 2022Article
- Corneal xenotransplantation: Where are we standing?Progress in retinal and eye research · 2021Review
- Efficacy of Lamellar Keratoplasty with Acellular Porcine Corneal Stroma in Treatment for Infectious Central and Peripheral Corneal Ulcers.Therapeutics and clinical risk management · 2021Article
- Tectonic Deep Anterior Lamellar Keratoplasty to Treat Corneal Perforation and Descemetocele from Microbial Keratitis.Clinical ophthalmology (Auckland, N.Z.) · 2021Article
- Experimental study of trabecular tissue repair for corneal defect in rabbits.International journal of ophthalmology · 2020Article
- Rejection of Acellular Porcine Corneal Stroma Transplantation During Coronavirus Disease 2019 Pandemic.The Journal of craniofacial surgeryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA worldwide lack of donor corneas demands the bioengineered corneas be developed as an alternative. The primary objective of the current study was to evaluate the efficacy of acellular porcine corneal stroma (APCS) transplantation in various types of infectious keratitis and identify risk factors that may increase APCS graft failure.
methodsIn this prospective interventional study, 39 patients with progressive infectious keratitis underwent therapeutic lamellar keratoplasty using APCS and were followed up for 12 months. Data collected for analysis included preoperative characteristics, visual acuity, graft survival and complications. Graft survival was evaluated by the Kaplan-Meier method and compared with the log-rank test.
resultsThe percentage of eyes that had a visual acuity of 20/40 or better increased from 10.3% preoperatively to 51.2% at 12 months postoperatively. Twelve patients (30.8%) experienced graft failure within the follow-up period. The primary reasons given for graft failure was noninfectious graft melting (n = 5), and the other causes included recurrence of primary infection (n = 4) and extensive graft neovascularization (n = 3). No graft rejection was observed during the follow-up period. A higher relative risk (RR) of graft failure was associated with herpetic keratitis (RR = 8.0, P = 0.046) and graft size larger than 8 mm (RR = 6.5, P < 0.001).
conclusionsAPCS transplantation is an alternative treatment option for eyes with medically unresponsive infectious keratitis. Despite the efficacy of therapeutic lamellar keratoplasty with APCS, to achieve a good prognosis, restriction of surgical indications, careful selection of patients and postoperative management must be emphasized. Trial registration Prospective Study of Deep Anterior Lamellar Keratoplasty Using Acellular Porcine Cornea, NCT03105466. Registered 31 August 2016, ClinicalTrails.gov.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.