Evidence map›Paper›PMID 31900183›Full record

ArticleDiagnostic pathology2020

Orbital involvement by NUT midline carcinoma: new presentation and encouraging outcome managed by radiotherapy combined with tyrosine kinase inhibitor: a case report.

Peiwei Chai, Chuandi Zhou, Renbing Jia, Yefei Wang

Open access · goldAbstract readCase Reports
In one paragraph

Article in Diagnostic pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. [A Case Report of Primary Pulmonary NUT Carcinoma and Literature Review].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2021
    Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Peiwei ChaiDepartment of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200025, People's Republic of China.
Chuandi ZhouDepartment of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200025, People's Republic of China.
Renbing JiaDepartment of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200025, People's Republic of China. renbingjia@sjtu.edu.cn.
Yefei WangDepartment of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200025, People's Republic of China. paper34@163.com.
Shanghai Ninth People's Hospital · CNShanghai Jiao Tong University · CN

Funding

UAB Center for Clinical and Translational Science (CCTS)U54TR001005 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KIMBERLY, ROBERT P. · 2014 to 2014
$4.6M
Innovation Fund for Translational Medicine 15ZH1005Innovative research team of high-level local universities in Shanghai Department of Ophthalmology, Shanghai Ninth People HospitalPh.D. Programs Foundation of Shanghai JiaoTong University School of Medicine BXJ201834The National Natural Science Foundation of China 81570884, 81770961the Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant 20152223the SMC-ChenXing Yong Scholar Program 2016, Class A
6 · The paper itself

Abstract

backgroundNUT midline carcinoma (NMC) is a poorly differentiated squamous cancer with a median survival at less than 7 months. NMC is resistant to conventional chemotherapies and characterized by rearrangement of the NUT gene. CASE PRESENTATION: Here, we described a patient who initially presented with epiphora, and an orbit involved NMC. In addition, we for the first time demonstrated that local radiotherapy combined with tyrosine kinase inhibitor (TKI) could significantly inhibit tumor progression in orbital involvement by NMC.

conclusionsOur study for the first time described an orbit involved NMC patient initially presented with epiphora. In addition, we provided an alternative to the management of orbit involved NMC.

Indexed as

Carcinoma, Squamous CellFemaleHumansIndolesLacrimal Apparatus DiseasesMiddle AgedNeoplasm ProteinsNuclear ProteinsOncogene ProteinsOrbitProtein-Tyrosine KinasesQuinolinesanlotinibIndolesNeoplasm ProteinsNuclear ProteinsNUTM1 protein, humanOncogene ProteinsProtein-Tyrosine KinasesQuinolinesAnlotinibEpiphoraNUT midline carcinomaTyrosine kinase inhibitor

Identifiers

PMID31900183
PMCPMC6942267
OpenAlexW3001044817

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.