ArticleJournal of biomedical science2020
Co-introduction of plasmids harbouring the carbapenemase genes, bla
Article in Journal of biomedical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Increased Carbapenem resistance and gene carriage in Pseudomonas aeruginosa clinical isolates after the COVID-19 pandemic in Egypt.Molecular biology reports · 2026Article
- Nationwide genomic surveillance of carbapenem- and colistin-resistant Klebsiella pneumoniae bloodstream isolates in Thailand (2020-2024).Scientific reports · 2026Article
- Epidemiology of ESBL-Producing, Carbapenem-Resistant, and Carbapenemase-Producing Enterobacterales in Southern Africa.Antibiotics (Basel, Switzerland) · 2026Review
- Prevalence and characterization of carbapenem-resistant gram-negative bacteria from poultry in Tamil Nadu, India.One health (Amsterdam, Netherlands) · 2025Article
- Different effects of plasmids harboringMicrobiology spectrum · 2025Article
- Capture of mobile genetic elements following intercellular conjugation promotes the production of ST11-KL64 CR-hvKP.Microbiology spectrum · 2025Article
- Unveiling the genetic architecture and transmission dynamics of a novel multidrug-resistant plasmid harboring blaBMC microbiology · 2024Article
- The effects of NDM-5 onFrontiers in microbiology · 2024Article
- The balance between antibiotic resistance and fitness/virulence inFrontiers in microbiology · 2023Review
- ISMicrobial genomics · 2022Article
- Predominance ofPathogens (Basel, Switzerland) · 2022Article
- Structural Diversity, Fitness Cost, and Stability of aMicroorganisms · 2021Article
- Article
- One-Step Detection and Classification of Bacterial Carbapenemases in 10 Minutes Using Fluorescence Identification of β-Lactamase Activity.Journal of clinical microbiology · 2021Article
- Co-Existence of Carbapenemase-Encoding Genes in Acinetobacter baumannii from Cancer Patients.Infectious diseases and therapy · 2021Article
- Genomic New Insights Into Emergence and Clinical Therapy of Multidrug-ResistantFrontiers in microbiology · 2021Article
- Emerging Transcriptional and Genomic Mechanisms Mediating Carbapenem and Polymyxin Resistance inmSystems · 2020Review
- Change of Hypermucoviscosity in the Development of Tigecycline Resistance in HypervirulentMicroorganisms · 2020Article
- Co-occurrence of genes encoding carbapenem resistance and aminoglycoside resistance in clinical isolates of Enterobacterales.Drug target insightsArticle
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundBacterial isolates with multiple plasmids harbouring different carbapenemase genes have emerged and been identified repeatedly, despite a general notion that plasmids confer fitness cost in bacterial host. In this study, we investigated the effects of plasmids with carbapenemase genes on the fitness and virulence of bacteria.
methodsDifferent plasmids harbouring the carbapenemase genes, bla
resultsThe transconjugants with a single plasmid showed identical phenotypes to the plasmid-free strain, except that they decreased fly survival after infection. However, significantly increased fitness, virulence and biofilm production were observed consistently for the transconjugant with both plasmids, harbouring bla
conclusionsOur data indicate that bacteria carrying multiple plasmids encoding different carbapenemases may have increased fitness and virulence, emphasizing the need for diverse strategies to combat antimicrobial resistance.
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