Evidence map›Paper›PMID 31900170›Full record

ArticleJournal of neuroinflammation2020

Short-term resistance exercise inhibits neuroinflammation and attenuates neuropathological changes in 3xTg Alzheimer's disease mice.

Yan Liu, John Man Tak Chu, Tim Yan, Yan Zhang, Ying Chen, Raymond Chuen Chung Chang, Gordon Tin Chun Wong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yan LiuDepartment of Anaesthesiology, LKS Faculty of Medicine, The University of Hong Kong, Room K424, Queen Mary Hospital, Pokfulam, Hong Kong, SAR, China.
John Man Tak ChuDepartment of Anaesthesiology, LKS Faculty of Medicine, The University of Hong Kong, Room K424, Queen Mary Hospital, Pokfulam, Hong Kong, SAR, China.
Tim YanLaboratory of Neurodegenerative Diseases, LKS Faculty of MedicineSchool of Biomedical Sciences, The University of Hong Kong, Hong Kong, SAR, China.
Yan ZhangDepartment of Anaesthesiology, LKS Faculty of Medicine, The University of Hong Kong, Room K424, Queen Mary Hospital, Pokfulam, Hong Kong, SAR, China.
Ying ChenDepartment of Anaesthesiology, LKS Faculty of Medicine, The University of Hong Kong, Room K424, Queen Mary Hospital, Pokfulam, Hong Kong, SAR, China.
Raymond Chuen Chung ChangLaboratory of Neurodegenerative Diseases, LKS Faculty of MedicineSchool of Biomedical Sciences, The University of Hong Kong, Hong Kong, SAR, China. rccchang@hku.hk.
Gordon Tin Chun WongDepartment of Anaesthesiology, LKS Faculty of Medicine, The University of Hong Kong, Room K424, Queen Mary Hospital, Pokfulam, Hong Kong, SAR, China. gordon@hku.hk.ORCID http://orcid.org/0000-0002-8127-4593

Funding

University Research Committee, University of Hong Kong 201511159317University Research Committee, University of Hong Kong 201611159054
6 · The paper itself

Abstract

backgroundBoth human and animal studies have shown beneficial effects of physical exercise on brain health but most tend to be based on aerobic rather than resistance type regimes. Resistance exercise has the advantage of improving both muscular and cardiovascular function, both of which can benefit the frail and the elderly. However, the neuroprotective effects of resistance training in cognitive impairment are not well characterized.

methodsWe evaluated whether short-term resistant training could improve cognitive function and pathological changes in mice with pre-existing cognitive impairment. Nine-month-old 3xTg mouse underwent a resistance training protocol of climbing up a 1-m ladder with a progressively heavier weight loading.

resultsCompared with sedentary counterparts, resistance training improved cognitive performance and reduced neuropathological and neuroinflammatory changes in the frontal cortex and hippocampus of mice. In line with these results, inhibition of pro-inflammatory intracellular pathways was also demonstrated.

conclusionsShort-term resistance training improved cognitive function in 3xTg mice, and conferred beneficial effects on neuroinflammation, amyloid and tau pathology, as well as synaptic plasticity. Resistance training may represent an alternative exercise strategy for delaying disease progression in Alzheimer's disease.

Indexed as

Alzheimer DiseaseAnimalsCognitionInflammationInflammation MediatorsMaleMaze LearningMiceMice, 129 StrainMice, TransgenicPhysical Conditioning, AnimalResistance TrainingTime FactorsInflammation MediatorsAlzheimer’s diseaseAmyloidCytokinesNeuroinflammationResistance exerciseSynapseTau

Identifiers

PMID31900170
PMCPMC6942350

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.