ArticleBMC ophthalmology2020
Dual effect of the Valsalva maneuver on autonomic nervous system activity, intraocular pressure, Schlemm's canal, and iridocorneal angle morphology.
Article in BMC ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Quantitative Changes in Iris Vessel Area Density During Valsalva Maneuver in Healthy Eyes.Translational vision science & technology · 2026Article
- Association Between Intraocular Pressure Changes and Optic Nerve Head and Macular Perfusion Parameters During Isometric Exercise: OCTA Study.Diagnostics (Basel, Switzerland) · 2026Article
- Association between blink-related anterior segment dynamics and intraocular pressure.Scientific reports · 2026Article
- Peripheral autonomic failure is associated with more severe postprandial hypotension compared to central autonomic failure.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Variations in Intraocular Pressure Among Athletes Across Different Sports Disciplines.Journal of clinical medicine · 2025Article
- The impact of different forms of exercise on intraocular pressure, blood flow, and the risk for primary open angle glaucoma.European journal of ophthalmology · 2025Review
- Evaluating the impact of caloric restriction, body mass index and exercise on primary open-angle glaucoma: A review.European journal of ophthalmology · 2025Review
- Article
- Evaluation of Retinal and Posterior Segment Vascular Changes Due to Systemic Hypoxia Using Optical Coherence Tomography Angiography.Journal of clinical medicine · 2024Article
- A potential compensatory mechanism for spaceflight associated neuro-ocular changes from microgravity: current understanding and future directions.Eye (London, England) · 2024Article
- Effect of wearing a surgical mask on intraocular pressure during COVID-19 pandemic.The Kaohsiung journal of medical sciences · 2024Article
- Pathological Mechanism and Clinical Therapy Progress of Schlemm's Canal.Journal of ophthalmology · 2024Review
- Effects of low-pressure Valsalva maneuver on changes in cerebral arterial stiffness and pulse wave velocity.PloS one · 2024Article
- Potential role ofNeural regeneration research · 2023Article
- Abnormal Systemic and Ocular Responses to the Valsalva Manoeuvre in Primary Open-Angle Glaucoma: A Case for Autonomic Failure?Current medical science · 2023Article
- Article
- Intraocular pressure fluctuation during resistance exercise.BMJ open ophthalmology · 2021Article
- Intraocular pressure increases during dynamic resistance training exercises according to the exercise phase in healthy young adults.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe Valsalva maneuver (VM) is widely used in daily life, and has been reported to cause high intraocular pressure (IOP). This study aimed to assess changes in IOP, the Schlemm's canal (SC), autonomic nervous system activity, and iridocorneal angle morphology in healthy individuals during different phases of the VM.
methodsThe high frequency (HF) of heart rate (HR) variability, the ratio of low frequency power (LF) and HF (LF/HF), heart rate (HR), IOP, systolic (SBP) and diastolic blood pressure (DBP), the area of SC (SCAR), pupil diameter (PD), and some iridocorneal angle parameters (AOD500, ARA750, TIA500 and TISA500) were measured in 29 young healthy individuals at baseline, phase 2, and phase 4 of the VM. SBP and DBP were measured to calculate mean arterial pressure (MAP) and mean ocular perfusion pressure (MOPP). HF and the LF/HF ratio were recorded using Kubios HR variability premium software to evaluate autonomic nervous system activity. The profiles of the anterior chamber were captured by a Spectralis optical coherence tomography device (anterior segment module).
resultsCompared with baseline values, in phase 2 of the VM, HR, LF/HF, IOP (15.1 ± 2.7 vs. 18.8 ± 3.5 mmHg, P < 0.001), SCAR (mean) (7712.112 ± 2992.14 vs. 8921.12 ± 4482.79 μm
conclusionsThe expansion and collapse of the SC in different phases of the VM may arise from changes in autonomic nervous system activity. Further, the effects of the VM on IOP may be attributed to changes in blood flow and ocular anatomy.
trial registrationThis observational study was approved by the ethics committee of Tongji Hospital (Registration Number: ChiCTR-OON-16007850, Date: 01.28.2016).
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