ArticleBMC genomics2020
Comprehensive genomic analysis of the DUF4228 gene family in land plants and expression profiling of ATDUF4228 under abiotic stresses.
Article in BMC genomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 32 citations in OpenAlex.
- The KeyPlants (Basel, Switzerland) · 2026Article
- Article
- Comprehensive genome-wide analysis of DUF668 gene family in potato reveals roles in growth and stress responses.Journal of applied genetics · 2026Article
- Genome-Scale Identification, Phylogeny, Expression Profiling, and Functional Analysis of Sugarcane DUF4228 Family Involved in Drought Stress.Plants (Basel, Switzerland) · 2026Article
- Article
- Genomic Regions Associated with Drought Tolerance and Other Traits in Lentils (Plants (Basel, Switzerland) · 2026Article
- Analysis of Genetic Variation of Rice Straw Characteristics and Its Influence on Biomass.Plant direct · 2026Article
- Article
- Genome-wide identification and characterization of DUF789 genes in cotton: implications for fibre development.BMC plant biology · 2025Article
- Article
- Genome-wide characterization and analysis of rice DUF247 gene family.BMC genomics · 2024Article
- Review
- Genomic wide association study and selective sweep analysis identify genes associated with improved yield under drought in Turkish winter wheat germplasm.Scientific reports · 2024Article
- Lineage-specific gene duplication and expansion of DUF1216 gene family in Brassicaceae.PloS one · 2024Article
- Genome-Wide Identification, Characterization and Expression Analysis of theInternational journal of molecular sciences · 2023Article
- Genome-Wide Analysis and Expression Profiling ofPlants (Basel, Switzerland) · 2023Article
- Unraveling the Diverse Roles of Neglected Genes Containing Domains of Unknown Function (DUFs): Progress and Perspective.International journal of molecular sciences · 2023Review
- Article
- A Comprehensive Analysis of the DUF4228 Gene Family inInternational journal of molecular sciences · 2022Article
- Overexpression of a DUF740 family gene (Frontiers in plant science · 2022Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundDomain of unknown function (DUF) proteins represent a number of gene families that encode functionally uncharacterized proteins in eukaryotes. The DUF4228 gene family is one of these families in plants that has not been described previously.
resultsIn this study, we performed an extensive comparative analysis of DUF4228 proteins and determined their phylogeny in the plant lineage. A total of 489 high-confidence DUF4228 family members were identified from 14 land plant species, which sub-divided into three distinct phylogenetic groups: group I, group II and group III. A highly conserved DUF4228 domain and motif distribution existed in each group, implying their functional conservation. To reveal the possible biological functions of these DUF4228 genes, 25 ATDUF4228 sequences from Arabidopsis thaliana were selected for further analysis of characteristics such as their chromosomal position, gene duplications and gene structures. Ka/Ks analysis identified seven segmental duplication events, while no tandemly duplication gene pairs were found in A. thaliana. Some cis-elements responding to abiotic stress and phytohormones were identified in the upstream sequences of the ATDUF4228 genes. Expression profiling of the ATDUF4228 genes under abiotic stresses (mainly osmotic, salt and cold) and protein-protein interaction prediction suggested that some ATDUF4228 genes are may be involved in the pathways of plant resistance to abiotic stresses.
conclusionThese results expand our knowledge of the evolution of the DUF4228 gene family in plants and will contribute to the elucidation of the biological functions of DUF4228 genes in the future.
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