Evidence map›Paper›PMID 31899864›Full record

ArticleBiochemistry2020

Tuning Allostery through Integration of Disorder to Order with a Residue Network.

Jingheng Wang, Riya Samanta, Gregory Custer, Christopher Look, Silvina Matysiak, Dorothy Beckett

Abstract read
In one paragraph

Article in Biochemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jingheng WangDepartment of Chemistry & Biochemistry , University of Maryland , College Park , Maryland 20742 , United States.
Riya SamantaBiophysics Graduate Program , University of Maryland , College Park , Maryland 20742 , United States.
Gregory CusterFischell Department of Bioengineering , University of Maryland , College Park , Maryland 20742 , United States.ORCID 0000-0002-9752-5748
Christopher LookFischell Department of Bioengineering , University of Maryland , College Park , Maryland 20742 , United States.
Silvina MatysiakFischell Department of Bioengineering , University of Maryland , College Park , Maryland 20742 , United States.ORCID 0000-0003-3824-9787
Dorothy BeckettDepartment of Chemistry & Biochemistry , University of Maryland , College Park , Maryland 20742 , United States.ORCID 0000-0002-7838-0651

Funding

Signal Propagation in Protein Allostery: Mechanism and EvolutionR01GM129327 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI WEBER, DAVID JOSEPH · 2019 to 2022
$1.3M
MASS SPECTROMETER SYSTEMS10RR015859 · NCRR · YESHIVA UNIVERSITY · PI ANGELETTI, RUTH HOGUE · 2001 to 2001
$485k
NCRR NIH HHS S10 RR015859NIGMS NIH HHS R01 GM129327
6 · The paper itself

Abstract

In allostery, a signal from one site in a protein is transmitted to a second site to alter its function. Due to its ubiquity in biology and the potential for its exploitation in drug and protein design, the molecular basis of allosteric communication continues to be the subject of intense research. Although allosterically coupled sites are frequently characterized by disorder, how communication between disordered segments occurs remains obscure. Allosteric activation of

Indexed as

Molecular Dynamics SimulationAllosteric RegulationCarbon-Nitrogen LigasesEscherichia coli ProteinsProtein MultimerizationProtein Structure, SecondaryRepressor ProteinsbirA protein, E coliCarbon-Nitrogen LigasesEscherichia coli ProteinsRepressor Proteins

Identifiers

PMID31899864
PMCPMC7759012

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.