Evidence map›Paper›PMID 31899786›Full record

ArticlePloS one2020

Discovery of Jogalong virus, a novel hepacivirus identified in a Culex annulirostris (Skuse) mosquito from the Kimberley region of Western Australia.

Simon H Williams, Avram Levy, Rachel A Yates, Nilusha Somaweera, Peter J Neville, Jay Nicholson, Michael D A Lindsay, John S Mackenzie, Komal Jain, Allison Imrie and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
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  3. A novel genotype ofFrontiers in cellular and infection microbiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Simon H WilliamsCenter for Infection and Immunity, Mailman School of Public Health of Columbia University, New York, New York, United States of America.ORCID 0000-0002-6276-4685
Avram LevyPathWest Laboratory Medicine WA, Nedlands, Western Australia, Australia.
Rachel A YatesCenter for Infection and Immunity, Mailman School of Public Health of Columbia University, New York, New York, United States of America.ORCID 0000-0002-0606-1395
Nilusha SomaweeraEnvironmental Health Directorate, Public and Aboriginal Health Division, Department of Health, Western Australia, Perth, Western Australia, Australia.
Peter J NevilleEnvironmental Health Directorate, Public and Aboriginal Health Division, Department of Health, Western Australia, Perth, Western Australia, Australia.
Jay NicholsonEnvironmental Health Directorate, Public and Aboriginal Health Division, Department of Health, Western Australia, Perth, Western Australia, Australia.
Michael D A LindsayEnvironmental Health Directorate, Public and Aboriginal Health Division, Department of Health, Western Australia, Perth, Western Australia, Australia.
John S MackenziePathWest Laboratory Medicine WA, Nedlands, Western Australia, Australia.
Komal JainCenter for Infection and Immunity, Mailman School of Public Health of Columbia University, New York, New York, United States of America.
Allison ImrieFaculty of Health and Medical Sciences, University of Western Australia, Nedlands, Western Australia, Australia.
David W SmithFaculty of Health and Medical Sciences, University of Western Australia, Nedlands, Western Australia, Australia.
W Ian LipkinCenter for Infection and Immunity, Mailman School of Public Health of Columbia University, New York, New York, United States of America.ORCID 0000-0002-8768-9386
Government of Western Australia Department of Health · AUColumbia University · USThe University of Western Australia · AUCurtin University · AUPathwest Laboratory Medicine · AU

Funding

Translational CoreU19AI109761 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BARIC, RALPH S · 2014 to 2018
$32.6M
NIAID NIH HHS U19 AI109761
6 · The paper itself

Abstract

The discovery of hepaciviruses in non-human hosts has accelerated following the advancement of high-throughput sequencing technology. Hepaciviruses have now been described in reptiles, fish, birds, and an extensive array of mammals. Using metagenomic sequencing on pooled samples of field-collected Culex annulirostris mosquitoes, we discovered a divergent hepacivirus-like sequence, named Jogalong virus, from the Kimberley region in northern Western Australia. Using PCR, we screened the same 300 individual mosquitoes and found just a single positive sample (1/300, 0.33%). Phylogenetic analysis of the hepacivirus NS5B protein places Jogalong virus within the genus Hepacivirus but on a distinct and deeply rooted monophyletic branch shared with duck hepacivirus, suggesting a notably different evolutionary history. Vertebrate barcoding PCR targeting two mitochondrial genes, cytochrome c oxidase subunit I and cytochrome b, indicated that the Jogalong virus-positive mosquito had recently fed on the tawny frogmouth (Podargus strigoides), although it is currently unknown whether this bird species contributes to the natural ecology of this virus.

Indexed as

Genome, ViralPhylogenyAnimalsCulexHepacivirusMosquito VectorsViral ProteinsWestern AustraliaViral Proteins

Identifiers

PMID31899786
PMCPMC6941808
OpenAlexW2997132598

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.