Observational studyOphthalmology2020
Measuring Glaucomatous Focal Perfusion Loss in the Peripapillary Retina Using OCT Angiography.
Observational study in Ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 29 citations in OpenAlex.
- A Comparison of Vessel Density in Primary Open-Angle Glaucoma and Normal-Tension Glaucoma Patients Using OCT Angiography [Letter].Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- A Comparison of Vessel Density in Primary Open-Angle Glaucoma and Normal-Tension Glaucoma Patients Using OCT Angiography.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Comparison of the number of peripapillary perforating scleral vessels between glaucomatous eyes and healthy eyes.Scientific reports · 2025Article
- Anatomy of the Macular Ganglion Cell Layer Plexus on Projection-Resolved Optical Coherence Tomographic Angiography.Translational vision science & technology · 2025Article
- The role of peripapillary vessel density and retinal nerve fiber layer thickness in diagnosing and monitoring myopic glaucoma.Frontiers in medicine · 2025Article
- Glaucomatous Focal Perfusion Loss in the Macula Measured by Optical Coherence Tomographic Angiography.American journal of ophthalmology · 2024Article
- Diagnostic performance of wide-field optical coherence tomography angiography for high myopic glaucoma.Scientific reports · 2024Observational
- Sector-Based Regression Strategies to Reduce Refractive Error-Associated Glaucoma Diagnostic Bias When Using OCT and OCT Angiography.Translational vision science & technology · 2023Article
- Longitudinal Observation of Retinal Response to Optic Nerve Transection in Rats Using Visible Light Optical Coherence Tomography.Investigative ophthalmology & visual science · 2023Article
- Diagnostic Accuracy of Imaging Devices in Glaucoma: An Updated Meta-Analysis.Medical journal of the Islamic Republic of Iran · 2023Article
- Reverse translation of artificial intelligence in glaucoma: Connecting basic science with clinical applications.Frontiers in ophthalmology · 2023Article
- Optical coherence tomographic angiography detects retinal vascular changes associated with pituitary adenoma.American journal of ophthalmology case reports · 2022Article
- Regression-Based Strategies to Reduce Refractive Error-Associated Glaucoma Diagnostic Bias When Using OCT and OCT Angiography.Translational vision science & technology · 2022Article
- Combining vascular and nerve fiber layer thickness measurements to model glaucomatous focal visual field loss.Annals of the New York Academy of Sciences · 2022Article
- Peripapillary vessel density correlates with visual field mean sensitivity in highly myopic eyes.Journal of translational medicine · 2022Article
- Vascular biomarkers from optical coherence tomography angiography and glaucoma: where do we stand in 2021?Acta ophthalmologica · 2022Review
- Optical coherence tomography.Nature reviews. Methods primers · 2022Article
- Combined wide-field optical coherence tomography angiography density map for high myopic glaucoma detection.Scientific reports · 2021Observational
- Hemiretinal Asymmetry in Peripapillary Vessel Density in Healthy, Glaucoma Suspect, and Glaucoma Eyes.American journal of ophthalmology · 2021Article
- Optical coherence tomographic angiography study of perfusion recovery after surgical lowering of intraocular pressure.Scientific reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo measure low perfusion areas (LPAs) and focal perfusion loss (FPL) in the peripapillary retina using OCT angiography (OCTA) in glaucoma.
designProspective, observational study.
participantsA total of 47 patients with primary open-angle glaucoma (POAG) and 36 normal participants were analyzed.
methodsOne eye of each subject was scanned using an AngioVue (Optovue, Fremont, CA) 4.5-mm OCTA scan centered on the disc. En face nerve fiber layer (NFL) plexus angiogram was generated. With the use of custom software, a capillary density map was obtained by computing the fraction of area occupied by flow pixels after low-pass filtering by local averaging 21×21 pixels. The low-perfusion map is defined by local capillary density below 0.5 percentile over a contiguous area above 98.5 percentile of the normal reference population. The LPA parameter is the cumulative area, and the FPL is the percent capillary density loss (relative to normal mean) integrated over the LPA.
main outcome measuresPeripapillary retinal LPA and FPL.
resultsAmong patients with POAG, 3 had preperimetric glaucoma and 44 had perimetric glaucoma, with visual field (VF) mean deviation (MD) of -5.14±4.25 decibels (dB). The LPA was 3.40±2.29 mm
conclusionsThe low-perfusion map and LPA and FPL parameters are able to assess the location and severity of focal glaucoma damage with good agreement with VF.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.