Evidence map›Paper›PMID 31898914›Full record

Trial reportCirculation. Genomic and precision medicine2020

Genome-Wide Polygenic Score and Cardiovascular Outcomes With Evacetrapib in Patients With High-Risk Vascular Disease: A Nested Case-Control Study.

Connor A Emdin, Pallav Bhatnagar, Minxian Wang, Sreekumar G Pillai, Lin Li, Hui-Rong Qian, Jeffrey S Riesmeyer, A Michael Lincoff, Stephen J Nicholls, Steven E Nissen and 3 more

Open access · bronzeAbstract readLetterRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Circulation. Genomic and precision medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Connor A EmdinCenter for Genomic Medicine, Massachusetts General Hospital, Boston (C.A.E., A.V.K.).
Pallav BhatnagarEli Lilly and Co, Indianapolis, IN (P.B., S.G.P., H.-R.Q., J.S.R., G.R.).
Minxian WangCardiovascular Disease Initiative, Broad Institute of MIT and Harvard (C.A.E., M.W., A.V.K.).
Sreekumar G PillaiEli Lilly and Co, Indianapolis, IN (P.B., S.G.P., H.-R.Q., J.S.R., G.R.).
Lin LiBioStat Solutions, Inc, Frederick, MD (L.L.).
Hui-Rong QianEli Lilly and Co, Indianapolis, IN (P.B., S.G.P., H.-R.Q., J.S.R., G.R.).
Jeffrey S RiesmeyerEli Lilly and Co, Indianapolis, IN (P.B., S.G.P., H.-R.Q., J.S.R., G.R.).
A Michael LincoffThe Cleveland Clinic Coordinating Center for Clinical Research, Department of Cardiovascular Medicine, Cleveland Clinic, OH (A.M.L., S.E.N.).
Stephen J NichollsMonash Cardiovascular Research Centre, Monash University, Clayton VIC, Australia (S.J.N.).
Steven E NissenThe Cleveland Clinic Coordinating Center for Clinical Research, Department of Cardiovascular Medicine, Cleveland Clinic, OH (A.M.L., S.E.N.).
Giacomo RuotoloEli Lilly and Co, Indianapolis, IN (P.B., S.G.P., H.-R.Q., J.S.R., G.R.).
Sekar KathiresanVerve Therapeutics, Cambridge, MA (S.K.).
Amit V KheraCenter for Genomic Medicine, Massachusetts General Hospital, Boston (C.A.E., A.V.K.).
Eli Lilly (United States) · USVerve Therapeutics (United States) · US

Funding

Polygenic prediction of common, complex diseasesK08HG010155 · NHGRI · MASSACHUSETTS GENERAL HOSPITAL · PI KHERA, AMIT VIKRAM · 2018 to 2021
$1.1M
NHGRI NIH HHS K08 HG010155
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Genome, HumanGenome-Wide Association StudyMultifactorial InheritanceAgedAnticholesteremic AgentsBenzodiazepinesCardiovascular DiseasesCase-Control StudiesFemaleHumansMalePharmacogenomic TestingRisk FactorsScotlandAnticholesteremic AgentsBenzodiazepinesevacetrapibcoronary artery diseaseepidemiologygeneticsgenome

Identifiers

PMID31898914
PMCPMC7031044
OpenAlexW3001809309

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.