Evidence map›Paper›PMID 31898886›Full record

ArticleACS chemical neuroscience2020

Evaluation of [

Vasko Kramer, Allen F Brooks, Arlette Haeger, Rodrigo O Kuljis, Waqas Rafique, Robert A Koeppe, David M Raffel, Kirk A Frey, Horacio Amaral, Peter J H Scott and 1 more

Open access · greenAbstract read
In one paragraph

Article in ACS chemical neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 27 citations in OpenAlex.

  1. Trifluoromethylation of alkyl electrophiles withScience (New York, N.Y.) · 2025
    Article
  2. Review
  3. Radiopharmaceuticals and their applications in medicine.Signal transduction and targeted therapy · 2025
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Diagnostic and Therapeutic Radiopharmaceuticals.ACS pharmacology & translational science · 2022
    Article
  11. Advances in [Molecules (Basel, Switzerland) · 2021
    Review
  12. Closing the gap betweenEJNMMI radiopharmacy and chemistry · 2021
    Review
  13. Synthesis of [ACS chemical neuroscience · 2021
    Article
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Vasko KramerCenter for Nuclear Medicine & PET/CT Positronmed , Providencia , 7501068 Santiago , Chile.ORCID 0000-0002-5285-6447
Allen F BrooksDepartment of Radiology , University of Michigan , Ann Arbor , Michigan 48109 , United States.ORCID 0000-0003-3773-3024
Arlette HaegerCenter for Nuclear Medicine & PET/CT Positronmed , Providencia , 7501068 Santiago , Chile.
Rodrigo O KuljisCenter for Nuclear Medicine & PET/CT Positronmed , Providencia , 7501068 Santiago , Chile.
Waqas Rafiquerealomics SRI, Kjemisk Institutt , Universitetet i Oslo , Sem Sælands vei 26 , Kjemibygningen, 0371 Oslo , Norway.
Robert A KoeppeDepartment of Radiology , University of Michigan , Ann Arbor , Michigan 48109 , United States.
David M RaffelDepartment of Radiology , University of Michigan , Ann Arbor , Michigan 48109 , United States.ORCID 0000-0002-7188-9463
Kirk A FreyDepartment of Radiology , University of Michigan , Ann Arbor , Michigan 48109 , United States.
Horacio AmaralCenter for Nuclear Medicine & PET/CT Positronmed , Providencia , 7501068 Santiago , Chile.
Peter J H ScottDepartment of Radiology , University of Michigan , Ann Arbor , Michigan 48109 , United States.ORCID 0000-0002-6505-0450
Patrick J Rissrealomics SRI, Kjemisk Institutt , Universitetet i Oslo , Sem Sælands vei 26 , Kjemibygningen, 0371 Oslo , Norway.ORCID 0000-0002-3887-7065
University of Michigan · USOslo University Hospital · NOUniversity of Oslo · NO

Funding

Michigan Institute for Clinical and Health Research (MICHR)UL1TR002240 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUMENG, JULIE C, MASHOUR, GEORGE ALEXANDER · 2017 to 2022
$54.9M
NCATS NIH HHS UL1 TR002240
6 · The paper itself

Abstract

Development of positron emission tomography (PET) imaging agents capable of quantifying tau aggregates in neurodegenerative disorders such as Alzheimer's disease (AD) is of enormous importance in the field of dementia research. The aim of the present study was to conduct first-in-man imaging studies with the potential novel tau imaging agent [

Indexed as

AgedAged, 80 and overAlzheimer DiseaseAniline CompoundsBrainCognitive DysfunctionEthylene GlycolsFemaleHumansLansoprazoleMaleMiddle AgedPositron-Emission TomographyTissue DistributionAniline CompoundsEthylene GlycolsflorbetapirLansoprazole[18F]N-Methyl LansoprazoleAlzheimer’s DiseaseNeurofibrillary tanglestau imaging

Identifiers

PMID31898886
PMCPMC7035908
OpenAlexW2997037476

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.