SynthesisObesity reviews : an official journal of the International Association for the Study of Obesity2020
Association of anthropometry and weight change with risk of dementia and its major subtypes: A meta-analysis consisting 2.8 million adults with 57 294 cases of dementia.
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In one paragraph
Synthesis in Obesity reviews : an official journal of the International Association for the Study of Obesity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 1 pooled it
13.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
60 citing papers in PubMed, 1 synthesis or guideline pooled it, 148 citations in OpenAlex.
- Association of anthropometry and weight change with risk of dementia and its major subtypes: A meta-analysis consisting 2.8 million adults with 57 294 cases of dementia.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2020Pooled it
- Trial
- Cardiometabolic measures and cognition in early menopause - Analysis of baseline data from a randomized controlled trial.Maturitas · 2022Trial
- Effects of obesity on brain health and cognition.Nature reviews. Neurology · 2026Review
- Dementia risk factor assessment in a local Alzheimer's prevention population: a German cross-sectional, observational study.The journal of prevention of Alzheimer's disease · 2026Observational
- The impact of slope-adjusted visit-to-visit body mass index variability on early dementia risk prediction.International journal of obesity (2005) · 2026Article
- Body mass index levels and changes before and after dementia diagnosis and risk of all-cause mortality: a nationwide cohort study.Alzheimer's research & therapy · 2026Article
- Sex differences in body mass index and waist circumference trajectories and dementia risk: the HUNT4 70+ study.GeroScience · 2026Article
- Construction of a classification model for dementia among Brazilian adults aged 50 and over.Frontiers in aging neuroscience · 2026Article
- Obesity, cardiometabolic health status, and brain health in community-dwelling older adults.Journal of Alzheimer's disease : JAD · 2026Article
- Stratifying dementia risk factors: A prediction model and hypothesis-driven analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Body weight trajectories from midlife are associated with cognitive decline in advanced age.Scientific reports · 2025Article
- The obesity paradox in cognitive decline: Impact of BMI dynamics and APOE genotypes across various cognitive status.Diabetes, obesity & metabolism · 2025Article
- The Association Between the Weight-Adjusted Waist Index and Dementia Risk in Older Adults: A Prospective Cohort Study.Healthcare (Basel, Switzerland) · 2025Article
- Association of Body Mass Index in Late Life, and Change from Midlife to Late Life, With Incident Dementia in the ARIC Study Participants.Neurology · 2025Observational
- Causal cardiovascular risk factors for dementia: insights from observational and genetic studies.Cardiovascular research · 2025Review
- 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2025Review
- Article
- How individual BMI affected general cognitive ability in young adults: a moderated chain mediation model.Frontiers in public health · 2025Article
- How is the brain affected by metabolically healthy or unhealthy obesity in adulthood and elderly? A narrative review of neuroimaging and neurocognitive findings.Frontiers in aging neuroscience · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
46 authors at 20 institutions in 10 countries.
Crystal ManYing LeeSchool of Psychology and Public Health, La Trobe University, Melbourne, Victoria, Australia.ORCID 0000-0001-6613-5491
Mark WoodwardThe George Institute for Global Health, University of Oxford, Oxford, UK.
G David BattyDepartment of Epidemiology and Public Health, University College London, London, UK.
Alexa S BeiserDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
Steven BellThe National Institute for Health Research Blood and Transplant Unit in Donor Health and Genomics, Strangeways Research Laboratory, University of Cambridge, Cambridge, UK.
Claudine BerrINSERM, U1061, Neuropsychiatry: Epidemiological and Clinical Research, University of Montpellier, Montpellier, France.
Espen BjertnessDepartment of Community Medicine and Global Health, University of Oslo, Oslo, Norway.
John ChalmersThe George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia.
Robert ClarkeClinical Trial Service Unit, Nuffield Department of Population health, University of Oxford, Oxford, UK.
Jean-Francois DartiguesUnité INSERM 1219, Université de Bordeaux, Bordeaux, France.
Kendra Davis-PlourdeDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
Stéphanie DebetteINSERM, Bordeaux Population Health Research Center and Department of Neurology, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France.
Emanuele Di AngelantonioThe National Institute for Health Research Blood and Transplant Unit in Donor Health and Genomics, Strangeways Research Laboratory, University of Cambridge, Cambridge, UK.
Catherine FeartINSERM, Bordeaux Population Health Research Center, UMR U1219, University of Bordeaux, Bordeaux, France.
Ruth Frikke-SchmidtDepartment of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark.
John GregsonDepartment of Medical Statistics, LSHTM, London, UK.
Mary N HaanDepartment of Epidemiology and Biostatistics, School of Medicine, University of California San Francisco, San Francisco, California, USA.
Linda B HassingDepartment of Psychology, and Centre for Ageing and Health - AgeCap, University of Gothenburg, Gothenburg, Sweden.
Kathleen M HaydenDepartment of Social Sciences and Health Policy, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Marieke P Hoevenaar-BlomDepartment of Neurology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Jaakko KaprioInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Mika KivimakiDepartment of Epidemiology and Public Health, University College London, London, UK.
Georgios LappasDepartment of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Eric B LarsonKaiser Permanente Washington Health Research Institute Seattle, Seattle, Washington, USA.
Erin S LeBlancKaiser Permanente Center for Health Research NW, Portland, Oregon, USA.
Anne LeeDepartment of Epidemiology and Biostatistics, School of Medicine, University of California San Francisco, San Francisco, California, USA.
Li-Yung LuiResearch Institute, California Pacific Medical Center, San Francisco, Carlifornia, USA.
Eric P Moll van CharanteDepartment of General Practice, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Toshiharu NinomiyaDepartment of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Liv Tybjaerg NordestgaardDepartment of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark.
Tomoyuki OharaDepartment of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Toshiaki OhkumaThe George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia.
Teemu PalviainenInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Karine PeresINSERM, Bordeaux Population Health Research Center, UMR U1219, University of Bordeaux, Bordeaux, France.
Ruth PetersFaculty of Science, University of New South Wales, Sydney, New South Wales, Australia.
Nawab QizilbashDepartment of Medical Statistics, LSHTM, London, UK.
Edo RichardDepartment of Neurology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Annika RosengrenDepartment of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Sudha SeshadriDepartment of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.
Martin ShipleyDepartment of Epidemiology and Public Health, University College London, London, UK.
Archana Singh-ManouxINSERM U1153, Hôpital Hôtel-Dieu, Paris, France.
Bjorn Heine StrandDepartment of Chronic Diseases and Ageing, Norwegian Institute of Public Health, Oslo, Norway.
Willem A van GoolDepartment of Neurology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Eero VuoksimaaInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Kristine YaffeDepartment of Psychiatry, University of California San Francisco, San Francisco, California, USA.
Rachel R HuxleyThe George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia.
University of Helsinki · FIBoston University · USInserm · FRUniversité de Bordeaux · FRUniversity of California, San Francisco · USUNSW Sydney · AUAmsterdam University Medical Centers · NLKyushu University · JPLondon School of Hygiene & Tropical Medicine · GBUniversity of Cambridge · GBUniversity of Copenhagen · DKUniversity of Gothenburg · SEAmsterdam Neuroscience · NLCalifornia Pacific Medical Center · USDeakin University · AUJohns Hopkins University · USKaiser Permanente Center for Health Research · USKaiser Permanente Washington Health Research Institute · USOregon State University · USOslo University Hospital · NO
Funding
Furthering scientific understanding of mechanisms underlying resilience to the effects of AD pathology by incorporating state of the art quantification of gliosis, inflammation, & synaptic toxicityU01AG006781 · NIA · UNIVERSITY OF WASHINGTON · PI CRANE, PAUL K, LARSON, ERIC B · 1986 to 2020
$39.3MSouth Texas Alzheimer's Disease Research CenterP30AG066546 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Sudha Seshadri · 2021 to 2026
$24.0MStudy of Osteoporotic FracturesR01AG005407 · NIA · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI CUMMINGS, STEVEN RON, YAFFE, KRISTINE · 1986 to 2016
$23.2MPRECURSORS OF STROKE INCIDENCE AND PROGNOSISR01NS017950 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Hugo Javier Aparicio, Jose Rafael Romero · 1985 to 2026
$22.9MTemporal Trends, Novel Imaging and Molecular Characterization of Preclinical and Clinical Alzheimer's Disease in the Framingham CohortsR01AG054076 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DECARLI, CHARLES, SESHADRI, SUDHA · 2016 to 2020
$12.3MEPIDEMIOLOGY OF DEMENTIA IN CACHE COUNTY, UTAHR01AG011380 · NIA · JOHNS HOPKINS UNIVERSITY · PI WELSH-BOHMER, KATHLEEN ANNE · 1994 to 2009
$12.2MCognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)RF1AG059421 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SESHADRI, SUDHA · 2018 to 2018
$6.1MStudy of Osteoporotic FracturesR01AG005394 · NIA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ENSRUD, KRISTINE · 1986 to 2015
$6.1MCollaborative GWAS of Dementia, AD and related MRI and Cognitive EndophenotypesR01AG033193 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI SESHADRI, SUDHA · 2009 to 2016
$4.4MClarifying risk and protective factors for dementia with the Interplay of Genes and Environment in Multiple Studies (IGEMS) consortiumR01AG060470 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GATZ, MARGARET, PEDERSEN, NANCY L · 2018 to 2022
$3.6MGene-Environment Interplay of Social Contexts and Aging-Related OutcomesR01AG037985 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PEDERSEN, NANCY L · 2010 to 2014
$3.2MSTUDY OF OSTEOPOROTIC FRACTURES: VERTEBRAL FRACTURESR01AR035583 · NIAMS · KAISER FOUNDATION RESEARCH INSTITUTE · PI HILLIER, TERESA A · 1986 to 2005
$3.2MBritish Heart Foundation RG/13/13/30194British Heart Foundation RG/18/13/33946Medical Research Council MR/L003120/1Medical Research Council MR/P023444/1Medical Research Council MR/R024227/1Medical Research Council MR/S011676/1NHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INIAMS NIH HHS R01 AR035582NIAMS NIH HHS R01 AR035583NIAMS NIH HHS R01 AR035584NIA NIH HHS P30 AG066546NIA NIH HHS R01 AG005394NIA NIH HHS R01 AG005407NIA NIH HHS R01 AG011380NIA NIH HHS R01 AG018712NIA NIH HHS R01 AG027574NIA NIH HHS R01 AG027576NIA NIH HHS R01 AG033193NIA NIH HHS R01 AG037985NIA NIH HHS R01 AG042633NIA NIH HHS R01 AG049607NIA NIH HHS R01 AG052519NIA NIH HHS R01 AG054076NIA NIH HHS R01 AG056477NIA NIH HHS R01 AG060470NIA NIH HHS R56 AG052519NIA NIH HHS RF1 AG059421NIA NIH HHS U01 AG006781NIA NIH HHS U01 AG049505NIA NIH HHS U01 AG052409NINDS NIH HHS R01 NS017950NINDS NIH HHS UH2 NS100605
Abstract
Uncertainty exists regarding the relation of body size and weight change with dementia risk. As populations continue to age and the global obesity epidemic shows no sign of waning, reliable quantification of such associations is important. We examined the relationship of body mass index, waist circumference, and annual percent weight change with risk of dementia and its subtypes by pooling data from 19 prospective cohort studies and four clinical trials using meta-analysis. Compared with body mass index-defined lower-normal weight (18.5-22.4 kg/m
Indexed as
AnthropometryAdultAgedBody Mass IndexBody SizeBody WeightDementiaDementia, VascularFemaleHumansMaleMiddle AgedObesityRisk FactorsThinnessWaist Circumference
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.