ArticleExperimental & applied acarology2020
Field evaluation of a novel oral reservoir-targeted vaccine against Borrelia burgdorferi utilizing an inactivated whole-cell bacterial antigen expression vehicle.
Article in Experimental & applied acarology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- A systematic review of the effectiveness and utility of Lyme disease prevention measures in Canada, the United States, and Europe.BMC infectious diseases · 2025Pooled it
- Curiouser and curiouser: understanding the intersection of inter- and intra-specific diversity during theInfection and immunity · 2026Review
- Protective efficacy of mutant strains ofInfection and immunity · 2026Article
- A double-blinded, placebo-controlled field trial of an OspA-based oral reservoir targeted vaccine against Borrelia burgdorferi.NPJ vaccines · 2026Article
- Why are the ticks winning, and what can we do about it?Ticks and tick-borne diseases · 2026Review
- A double-blinded, placebo-controlled field trial of an OspA-based oral reservoir targeted vaccine againstbioRxiv : the preprint server for biology · 2026Article
- Efficacy of Purified Borrelial Lipoproteins (PBL) as an oral formulation in reducing transmission of Lyme spirochetes from reservoir hosts tobioRxiv : the preprint server for biology · 2026Article
- Hygromycin A Treatment of Borrelia burgdorferi-Infected Peromyscus leucopus Suggests Potential as a Reservoir-Targeted Antibiotic.The Journal of infectious diseases · 2026Article
- Maternal transfer of oral vaccine induced anti-OspA antibodies protectsInfection and immunity · 2025Article
- Minor Hosts Have a Major Impact on the Enzootic Transmission of Borrelia burgdorferi.The American journal of tropical medicine and hygiene · 2025Article
- Oral delivery of bovine tuberculosis vaccine to free-ranging white-tailed deer.Frontiers in veterinary science · 2025Article
- One Health, many approaches: integrated vector management strategies support One Health goals.Frontiers in insect science · 2025Review
- Article
- Deployment of a Reservoir-Targeted Vaccine Against Borrelia burgdorferi Reduces the Prevalence of Babesia microti Coinfection in Ixodes scapularis Ticks.The Journal of infectious diseases · 2023Article
- Safety and immunogenicity of orally administered poxvirus vectored constructs in the white-footed mouse (Vaccine: X · 2023Article
- Rodent-targeted approaches to reduce acarological risk of human exposure to pathogen-infected Ixodes ticks.Ticks and tick-borne diseases · 2023Review
- Barriers to Effective Tick Management and Tick-Bite Prevention in the United States (Acari: Ixodidae).Journal of medical entomology · 2021Article
- Review
- Control of ixodid ticks and prevention of tick-borne diseases in the United States: The prospect of a new Lyme disease vaccine and the continuing problem with tick exposure on residential properties.Ticks and tick-borne diseases · 2021Review
- Humane Use of Cardiac Puncture for Non-Terminal Phlebotomy of Wild-Caught and ReleasedAnimals : an open access journal from MDPI · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Blacklegged ticks (Ixodes scapularis) are the principal vector for Borrelia burgdorferi, among other infectious agents, in the northeastern, mid-Atlantic, and upper midwestern USA. White-footed mice (Peromyscus leucopus) are the primary and most competent reservoir host of B. burgdorferi in the Northeast. Live reservoir-targeted vaccines (RTVs) to limit enzootic transmission of B. burgdorferi were previously developed and successfully evaluated in laboratory and controlled field trials. A novel, inactivated RTV was developed to minimize regulatory and market challenges facing previous RTVs based on live bacterial or viral vehicles. Thirty-two residential properties in Redding, Connecticut, participated in a field trial of an orally delivered, inactivated RTV efficacy study (2015-2016). During the two-year vaccination period, a significant decrease in the percentage of B. burgdorferi-infected I. scapularis larvae parasitizing P. leucopus was observed, as was a significant reduction in the percentage of infected P. leucopus on RTV-treated properties when compared to control properties. This novel inactivated RTV was effective in reducing numbers of B. burgdorferi-infected I. scapularis and B. burgdorferi-infected P. leucopus on properties where it was distributed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.