Evidence map›Paper›PMID 31898525›Full record

ArticleBMC psychiatry2020

Consortium on Vulnerability to Externalizing Disorders and Addictions (cVEDA): A developmental cohort study protocol.

Eesha Sharma, Nilakshi Vaidya, Udita Iyengar, Yuning Zhang, Bharath Holla, Meera Purushottam, Amit Chakrabarti, Gwen Sascha Fernandes, Jon Heron, Matthew Hickman and 28 more

Abstract read
In one paragraph

Article in BMC psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. A cross ancestry genetic study of psychiatric disorders from India.medRxiv : the preprint server for health sciences · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors.

Eesha SharmaDepartment of Child and Adolescent Psychiatry, National Institute of Mental Health and Neuro-Sciences (NIMHANS), Bangalore, Karnataka, India. eesha.250@gmail.com.
Nilakshi VaidyaCentre for Population Neuroscience and Precision Medicine, Institute of Psychology, Psychiatry & Neuroscience, MRC SGDP Centre, King's College London, London, UK.
Udita IyengarDepartment of Child & Adolescent Psychiatry, Institute of Psychology, Psychiatry & Neuroscience, King's College London, London, UK.
Yuning ZhangCentre for Population Neuroscience and Precision Medicine, Institute of Psychology, Psychiatry & Neuroscience, MRC SGDP Centre, King's College London, London, UK.
Bharath HollaDepartment of Psychiatry, National Institute of Mental Health and Neuro-Sciences (NIMHANS), Bangalore, Karnataka, India.
Meera PurushottamMolecular Genetics Laboratory, National Institute of Mental Health and Neuro-Sciences (NIMHANS), Bangalore, Karnataka, India.
Amit ChakrabartiRegional Occupational Health Centre (ROHC), Eastern, ICMR-National Institute of Occupational Health (NIOH), Kolkata, West Bengal, India.
Gwen Sascha FernandesPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Jon HeronPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Matthew HickmanPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Sylvane DesrivieresCentre for Population Neuroscience and Precision Medicine, Institute of Psychology, Psychiatry & Neuroscience, MRC SGDP Centre, King's College London, London, UK.
Kamakshi KartikRishi Valley Rural Health Centre, Madanapalle, Chittoor, Andhra Pradesh, India.
Preeti JacobDepartment of Child and Adolescent Psychiatry, National Institute of Mental Health and Neuro-Sciences (NIMHANS), Bangalore, Karnataka, India.
Madhavi RangaswamyDepartment of Psychology, Christ University, Bangalore, Karnataka, India.
Rose Dawn BharathDepartment of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neuro-Sciences (NIMHANS), Bangalore, Karnataka, India.
Gareth BarkerDepartment of Neuroimaging, Institute of Psychology, Psychiatry & Neuroscience, King's College London, London, UK.
Dimitri Papadopoulos OrfanosNeuroSpin, CEA, Université Paris-Saclay, Paris, France.
Chirag AhujaDepartment of Radiodiagnosis and Imaging, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Pratima MurthyDepartment of Psychiatry, National Institute of Mental Health and Neuro-Sciences (NIMHANS), Bangalore, Karnataka, India.
Sanjeev JainDepartment of Psychiatry, National Institute of Mental Health and Neuro-Sciences (NIMHANS), Bangalore, Karnataka, India.
Mathew VargheseDepartment of Psychiatry, National Institute of Mental Health and Neuro-Sciences (NIMHANS), Bangalore, Karnataka, India.
Deepak JayarajanDepartment of Psychiatry, National Institute of Mental Health and Neuro-Sciences (NIMHANS), Bangalore, Karnataka, India.
Keshav KumarDepartment of Mental Health and Clinical Psychology, National Institute of Mental Health and Neuro-Sciences (NIMHANS), Bangalore, Karnataka, India.
Kandavel ThennarasuDepartment of Biostatistics, National Institute of Mental Health and Neuro-Sciences (NIMHANS), Bangalore, Karnataka, India.
Debashish BasuDepartment of Psychiatry, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
B N SubodhDepartment of Psychiatry, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Rebecca KuriyanDivision of Nutrition, St John's Research Institute, Bengaluru, India.
Sunita Simon KurpadDepartment of Psychiatry & Department of Medical Ethics, St. John's Medical College & Hospital, Bengaluru, India.
Kumaran KalyanramMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
Ghattu KrishnaveniEpidemiology Research Unit, CSI Holdsworth Memorial Hospital, Mysore, India.
Murali KrishnaFoundation for Research and Advocacy in Mental Health, Mysore, India.
Rajkumar Lenin SinghDepartment of Psychiatry, Regional Institute of Medical Sciences (RIMS), Imphal, Manipur, India.
L Roshan SinghDepartment of Clinical Psychology, Regional Institute of Medical Sciences (RIMS), Imphal, Manipur, India.
Kartik KalyanramRishi Valley Rural Health Centre, Madanapalle, Chittoor, Andhra Pradesh, India.
Mireille ToledanoFaculty of Medicine, School of Public Health, Imperial College, London, UK.
Gunter SchumannCentre for Population Neuroscience and Precision Medicine, Institute of Psychology, Psychiatry & Neuroscience, MRC SGDP Centre, King's College London, London, UK.
Vivek BenegalDepartment of Psychiatry, National Institute of Mental Health and Neuro-Sciences (NIMHANS), Bangalore, Karnataka, India.
cVEDA Consortium

Funding

Medical Research Council MC_PC_19009Medical Research Council MR/L022206/1Medical Research Council MR/N000390/1Medical Research Council MR/S019669/1
6 · The paper itself

Abstract

backgroundLow and middle-income countries like India with a large youth population experience a different environment from that of high-income countries. The Consortium on Vulnerability to Externalizing Disorders and Addictions (cVEDA), based in India, aims to examine environmental influences on genomic variations, neurodevelopmental trajectories and vulnerability to psychopathology, with a focus on externalizing disorders.

methodscVEDA is a longitudinal cohort study, with planned missingness design for yearly follow-up. Participants have been recruited from multi-site tertiary care mental health settings, local communities, schools and colleges. 10,000 individuals between 6 and 23 years of age, of all genders, representing five geographically, ethnically, and socio-culturally distinct regions in India, and exposures to variations in early life adversity (psychosocial, nutritional, toxic exposures, slum-habitats, socio-political conflicts, urban/rural living, mental illness in the family) have been assessed using age-appropriate instruments to capture socio-demographic information, temperament, environmental exposures, parenting, psychiatric morbidity, and neuropsychological functioning. Blood/saliva and urine samples have been collected for genetic, epigenetic and toxicological (heavy metals, volatile organic compounds) studies. Structural (T1, T2, DTI) and functional (resting state fMRI) MRI brain scans have been performed on approximately 15% of the individuals. All data and biological samples are maintained in a databank and biobank, respectively. DISCUSSION: The cVEDA has established the largest neurodevelopmental database in India, comparable to global datasets, with detailed environmental characterization. This should permit identification of environmental and genetic vulnerabilities to psychopathology within a developmental framework. Neuroimaging and neuropsychological data from this study are already yielding insights on brain growth and maturation patterns.

Indexed as

Child DevelopmentAdolescentBehavior, AddictiveChildChild, PreschoolCohort StudiesFemaleFollow-Up StudiesHumansIndiaInfantInfant, NewbornLongitudinal StudiesMaleMental DisordersParentingCohortEnvironmental exposuresExternalizing disordersLongitudinal studyStudy protocolVulnerabilities

Identifiers

PMID31898525
PMCPMC6941284

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.