Observational studyThe journal of headache and pain2020
White matter changes in chronic and episodic migraine: a diffusion tensor imaging study.
Observational study in The journal of headache and pain, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06244823 (A Prospective Structural, Diffusion and Connectomics MRI Study on Migraine Patients Treated With Fremanezumab), which is not on this map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective Structural, Diffusion and Connectomics MRI Study on Migraine Patients Treated With Fremanezumab: The FreMRI Study
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.
- Microstructural white matter alterations associated with migraine headaches: a systematic review of diffusion tensor imaging studies.Brain imaging and behavior · 2022Pooled it
- Abnormal structural connectivity-functional connectivity coupling beyond the cortex in patients with chronic migraine.The journal of headache and pain · 2026Article
- Epigenetics in migraine: the Junior Editorial Board Members' vision.The journal of headache and pain · 2025Review
- Diffusion Tensor Imaging-Based Glymphatic Dysfunction Assessments in Migraine Syndromes: Mechanisms and Diagnostic Implications.Biomedicines · 2025Review
- Article
- Trigeminal nerve microstructure is linked with neuroinflammation and brainstem activity in migraine.Brain : a journal of neurology · 2025Article
- Functional and Structural Differences of Brain in Patients With Vestibular Migraine: A Resting-State Functional MRI and DTI Study.Brain and behavior · 2025Article
- White matter and cortical gray matter microstructural alterations in migraine: a NODDI and DTI analysis.The journal of headache and pain · 2025Article
- White matter alterations in episodic migraine without aura patients assessed with diffusion MRI: effect of free water correction.The journal of headache and pain · 2025Article
- fMRI Insights into Visual Cortex Dysfunction as a Biomarker for Migraine with Aura.Neurology international · 2025Review
- Analysis of the relationships between the degree of migraine with right-to-left shunts and changes in white matter lesions and brain structural volume.Scientific reports · 2025Article
- Causal Relationship Between Migraine and Postpartum Depression: A Two-Sample Bidirectional Mendelian Randomization Study.Journal of pain research · 2025Article
- Association between white matter microstructural and functional abnormalities and clinical characteristics in migraine without aura: a mediation analysis.Frontiers in neurology · 2025Article
- Preventive treatment effects on brain structures and functions in patients with chronic migraine: A multimodel magnetic resonance imaging study.The Kaohsiung journal of medical sciences · 2024Article
- Brain structures as potential mediators of the causal effect of COVID 19 on migraine risk.Scientific reports · 2024Article
- Morphological similarity and white matter structural mapping of new daily persistent headache: a structural connectivity and tract-specific study.The journal of headache and pain · 2024Article
- Causal relationships between cortical brain structural alterations and migraine subtypes: a bidirectional Mendelian randomization study of 2,347 neuroimaging phenotypes.The journal of headache and pain · 2024Article
- Neurite Damage in Patients with Migraine.Neurology international · 2024Article
- Association between risk factors and migraine in Pakistani females.BMC women's health · 2023Article
- Increased MRI-based Brain Age in chronic migraine patients.The journal of headache and pain · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundWhite matter alterations have been observed in patients with migraine. However, no microstructural white matter alterations have been found particularly in episodic or chronic migraine patients, and there is limited research focused on the comparison between these two groups of migraine patients.
methodsFifty-one healthy controls, 55 episodic migraine patients and 57 chronic migraine patients were recruited and underwent brain T1-weighted and diffusion-weighted MRI acquisition. Using Tract-Based Spatial Statistics (TBSS), fractional anisotropy, mean diffusivity, radial diffusivity and axial diffusivity were compared between the different groups. On the one hand, all migraine patients were compared against healthy controls. On the other hand, patients from each migraine group were compared between them and also against healthy controls. Correlation analysis between clinical features (duration of migraine in years, time from onset of chronic migraine in months, where applicable, and headache and migraine frequency, where applicable) and Diffusion Tensor Imaging measures was performed.
resultsFifty healthy controls, 54 episodic migraine and 56 chronic migraine patients were finally included in the analysis. Significant decreased axial diffusivity (p < .05 false discovery rate and by number of contrasts corrected) was found in chronic migraine compared to episodic migraine in 38 white matter regions from the Johns Hopkins University ICBM-DTI-81 White-Matter Atlas. Significant positive correlation was found between time from onset of chronic migraine and mean fractional anisotropy in the bilateral external capsule, and negative correlation between time from onset of chronic migraine and mean radial diffusivity in the bilateral external capsule.
conclusionsThese findings suggest global white matter structural differences between episodic migraine and chronic migraine. Patients with chronic migraine could present axonal integrity impairment in the first months of chronic migraine with respect to episodic migraine patients. White matter changes after the onset of chronic migraine might reflect a set of maladaptive plastic changes.
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Registered trials
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