SynthesisInternational wound journal2020
Pain in persons with chronic venous leg ulcers: A systematic review and meta-analysis.
Synthesis in International wound journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- The Effectiveness, Safety and Cost-Effectiveness of Platelet-Rich Plasma and Platelet-Rich Fibrin in the Treatment of Venous Leg Ulcers: A Systematic Review and Meta-Analysis.International wound journal · 2026Pooled it
- Pain in persons with chronic venous leg ulcers: A systematic review and meta-analysis.International wound journal · 2020Pooled it
- Assessing the Safety, Tolerability and Efficacy of Cell-Free Amniotic Fluid in the Treatment of Non-Healing Venous Ulcers: Initial Experience From a Prospective, Multicenter, Phase II Study.International wound journal · 2025Trial
- Psychometric Validation of the Spanish Version of the Sheffield Preference-Based Venous Leg Ulcer Questionnaire (SPVU-5D) in Patients With Venous Leg Ulcers.International wound journal · 2026Article
- Neuromuscular Stimulation of the Common Peroneal Nerve: Improved Pain Trajectory in Chronic Venous Leg Ulcers.Journal of clinical medicine · 2026Article
- Invisible Agency in the Search for Healing: Patient and Family Roles in the Care of Hard-to-Heal Wounds in Primary Healthcare.International wound journal · 2026Article
- Pharmacological Pain Management in Adults with Venous Ulceration: A Systematic Review.Journal of pain research · 2026Review
- Factors Associated With Quality of Life in Patients With Venous Leg Ulcers in a Community Setting: A Cross-Sectional Study.Health science reports · 2025Article
- Making Conscientious Decisions: Engaging in Venous Leg Ulcer Self-Management Following Nurse-Led Patient Education.Qualitative health research · 2025Article
- Sleep, Fatigue, and Inflammatory Biomarkers in Older Adults with Chronic Venous Leg Ulcers Receiving Intensive Outpatient Wound Care.Advances in wound care · 2024Article
- High Symptom Burden in Patients With Advanced Chronic or Prolonged Infectious Diseases: Not Only Pain.Cureus · 2024Article
- Exploring the effect of wound related pain on psychological stress, inflammatory response, and wound healing.International wound journal · 2024Observational
- Systematic review of topical interventions for the management of pain in chronic wounds.Pain reports · 2023Review
- The association of wound factors and symptoms of fatigue and pain with wound healing in chronic venous leg ulcers.International wound journal · 2023Article
- A Highly Efficacious Electrical Biofilm Treatment System for Combating Chronic Wound Bacterial Infections.Advanced materials (Deerfield Beach, Fla.) · 2023Article
- Biofilms in Chronic Wound Infections: Innovative Antimicrobial Approaches Using the In Vitro Lubbock Chronic Wound Biofilm Model.International journal of molecular sciences · 2023Review
- Observational
- Background pain in persons with chronic leg ulcers: An exploratory study of symptom characteristics and management.International wound journal · 2022Article
- Homocysteine and Inflammatory Cytokines in the Clinical Assessment of Infection in Venous Leg Ulcers.Antibiotics (Basel, Switzerland) · 2022Article
- Potential predictors of quality of life in patients with venous leg ulcers: A cross-sectional study in Taiwan.International wound journal · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pain is a serious problem for patients with leg ulcers. Research mainly focuses on dressing-related pain; however, chronic background pain may be just as devastating. Our main objective was to describe the prevalence and characteristics of wound-related background pain in persons with chronic venous leg ulcers. We performed a systematic review to synthesise data from quantitative studies. Studies were eligible if they reported original baseline- or cross-sectional data on background pain in chronic venous leg ulcers. The initial search identified 2454 publications. We included 36 descriptive and effect studies. The pooled prevalence of wound-related background pain (from 10 studies) was 80% (95% CI 65-92%). The mean pain intensity score (from 27 studies) was 4 (0-10 numeric rating scale) (95% CI 3.4-4.5). Other pain characteristics could not be synthesised. We identified few sufficiently high-quality studies on prevalence and intensity of wound-related background pain in patients with chronic venous leg ulcers. Four of five persons experience mild to moderate pain. Because of poor quality of pain assessment and report, we believe that the available research does not provide a sufficiently nuanced understanding of background pain in this patient group.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.