Evidence map›Paper›PMID 31898295›Full record

ArticleBehavior research methods2020

MixWILD: A program for examining the effects of variance and slope of time-varying variables in intensive longitudinal data.

Eldin Dzubur, Aditya Ponnada, Rachel Nordgren, Chih-Hsiang Yang, Stephen Intille, Genevieve Dunton, Donald Hedeker

Abstract read
In one paragraph

Article in Behavior research methods, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

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  11. Longitudinal User Engagement with Microinteraction Ecological Momentary Assessment (μEMA).Proceedings of the ACM on interactive, mobile, wearable and ubiquitous technologies · 2025
    Article
  12. Article
  13. SPANature communications · 2025
    Article
  14. Article
  15. Mixed-Effects Location Scale Models for Joint Modeling School Value-Added Effects on the Mean and Variance of Student Achievement.Journal of educational and behavioral statistics : a quarterly publication sponsored by the American Educational Research Association and the American Statistical Association · 2024
    Article
  16. Pleasure and Satisfaction as Predictors of Future Cigarette and E-cigarette Use: A Novel Two-Stage Modeling Approach.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2024
    Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Eldin DzuburUniversity of Southern California, Los Angeles, CA, USA. dzubur@usc.edu.
Aditya PonnadaNortheastern University, Boston, MA, USA.
Rachel NordgrenUniversity of Illinois - Chicago, Chicago, IL, USA.
Chih-Hsiang YangUniversity of Southern California, Los Angeles, CA, USA.
Stephen IntilleNortheastern University, Boston, MA, USA.
Genevieve DuntonUniversity of Southern California, Los Angeles, CA, USA.
Donald HedekerUniversity of Chicago, Chicago, IL, USA.

Funding

Novel Statistical Models for Intensive Longitudinal Analyses of Cancer Control BehaviorsR01CA240713 · NCI · UNIVERSITY OF CHICAGO · PI Genevieve Fridlund Dunton, Donald Hedeker · 2019 to 2026
$4.1M
Novel Statistical Models for EMA Studies of Physical ActivityR01HL121330 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DUNTON, GENEVIEVE FRIDLUND, HEDEKER, DONALD · 2014 to 2017
$2.0M
NCI NIH HHS R01 CA240713NHLBI NIH HHS R01 HL121330
6 · The paper itself

Abstract

The use of intensive sampling methods, such as ecological momentary assessment (EMA), is increasingly prominent in medical research. However, inferences from such data are often limited to the subject-specific mean of the outcome and between-subject variance (i.e., random intercept), despite the capability to examine within-subject variance (i.e., random scale) and associations between covariates and subject-specific mean (i.e., random slope). MixWILD (Mixed model analysis With Intensive Longitudinal Data) is statistical software that tests the effects of subject-level parameters (variance and slope) of time-varying variables, specifically in the context of studies using intensive sampling methods, such as ecological momentary assessment. MixWILD combines estimation of a stage 1 mixed-effects location-scale (MELS) model, including estimation of the subject-specific random effects, with a subsequent stage 2 linear or binary/ordinal logistic regression in which values sampled from each subject's random effect distributions can be used as regressors (and then the results are aggregated across replications). Computations within MixWILD were written in FORTRAN and use maximum likelihood estimation, utilizing both the expectation-maximization (EM) algorithm and a Newton-Raphson solution. The mean and variance of each individual's random effects used in the sampling are estimated using empirical Bayes equations. This manuscript details the underlying procedures and provides examples illustrating standalone usage and features of MixWILD and its GUI. MixWILD is generalizable to a variety of data collection strategies (i.e., EMA, sensors) as a robust and reproducible method to test predictors of variability in level 1 outcomes and the associations between subject-level parameters (variances and slopes) and level 2 outcomes.

Indexed as

BiometrySoftwareBayes TheoremBiomedical ResearchLogistic ModelsLongitudinal StudiesResearch DesignEcological momentary assessmentHeteroscedasticityIntensive longitudinal dataMixed modelsMultilevelVariance modeling

Identifiers

PMID31898295
PMCPMC7406537

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.