ReviewNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2020
Considering Drug-Associated Contexts in Substance Use Disorders and Treatment Development.
Review in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Brain connectivity changes to fast versus slow dopamine increases.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Trial
- Context Memory Discrimination and Recognition in Humans: Development of a Novel Cognitive Task.JMIR formative research · 2026Article
- Context-Dependent Extinction and Return of Pavlovian Alcohol-Seeking Behavior in Male and Female Rats.Alcohol, clinical & experimental research · 2026Article
- Context features influence alcohol reward and motivation.Alcohol, clinical & experimental research · 2026Article
- Hippocampal Cofilin and CFL1 gene variants are linked to Alcohol Use Disorder phenotypes.Molecular psychiatry · 2026Article
- Regulation of addiction by the insular cortex: The interplay between interoception and cognitive function.iScience · 2025Review
- Decreased incubation of fentanyl seeking in the absence of proximal drug-paired stimuli.Experimental and clinical psychopharmacology · 2025Article
- Loneliness partially mediates the relation between substance use and suicidality in Veterans.Military psychology : the official journal of the Division of Military Psychology, American Psychological Association · 2025Article
- Modulation of Alcohol Use Disorder by Brain Stimulation.Current topics in behavioral neurosciences · 2025Review
- Self-administration acquisition latency predicts locomotor sensitivity to cocaine in male rats.Behavioural brain research · 2024Article
- Neuropathic pain has sex-specific effects on oxycodone-seeking and non-drug-seeking ensemble neurons in the dorsomedial prefrontal cortex of mice.Addiction biology · 2024Article
- Self-regulation training generalizability using the regulation of craving task. An fMRI study.Frontiers in psychology · 2024Article
- Neural circuit selective for fast but not slow dopamine increases in drug reward.Nature communications · 2023Article
- Neuroplastic Changes in Addiction Memory-How Music Therapy and Music-Based Intervention May Reduce Craving: A Narrative Review.Brain sciences · 2023Review
- Cue-reactivity targeted smoking cessation intervention in individuals with tobacco use disorder: a scoping review.Frontiers in psychiatry · 2023Article
- Predator odor (TMT) exposure potentiates interoceptive sensitivity to alcohol and increases GABAergic gene expression in the anterior insular cortex and nucleus accumbens in male rats.Alcohol (Fayetteville, N.Y.) · 2022Article
- Disrupting reconsolidation by PKA inhibitor in BLA reduces heroin-seeking behavior.Frontiers in cellular neuroscience · 2022Article
- Low-dose alcohol: Interoceptive and molecular effects and the role of dentate gyrus in rats.Addiction biology · 2021Article
- Chronic nicotine increases alcohol self-administration in adult male Wistar rats.Psychopharmacology · 2021Article
- Dissociable mesolimbic dopamine circuits control responding triggered by alcohol-predictive discrete cues and contexts.Nature communications · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Environmental contexts that are reliably associated with the use of pharmacologically active substances are hypothesized to contribute to substance use disorders. In this review, we provide an updated summary of parallel preclinical and human studies that support this hypothesis. Research conducted in rats shows that environmental contexts that are reliably paired with drug use can renew extinguished drug-seeking behavior and amplify responding elicited by discrete, drug-predictive cues. Akin to drug-associated contexts, interoceptive drug stimuli produced by the psychopharmacological effects of drugs can also influence learning and memory processes that play a role in substance use disorders. Findings from human laboratory studies show that drug-associated contexts, including social stimuli, can have profound effects on cue reactivity, drug use, and drug-related cognitive expectancies. This translationally relevant research supports the idea that treatments for substance use disorders could be improved by considering drug-associated contexts as a factor in treatment interventions. We conclude this review with ideas for how to integrate drug-associated contexts into treatment-oriented research based on 4 approaches: pharmacology, brain stimulation, mindfulness-based relapse prevention, and cognitive behavioral group therapy. Throughout, we focus on alcohol- and tobacco-related research, which are two of the most prevalent and commonly misused drugs worldwide for which there are known treatments.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.