Evidence map›Paper›PMID 31898110›Full record

ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2021

Endoscopic Papillectomy for Ampullary Adenomas: Different Outcomes in Sporadic Tumors and Those Associated with Familial Adenomatous Polyposis.

Paolo Cecinato, Francesca Parmeggiani, Luca Braglia, Gabriele Carlinfante, Ramona Zecchini, Francesco Decembrino, Veronica Iori, Giuliana Sereni, Cristiana Tioli, Maurizio Cavina and 4 more

2 registry-linked trialsAbstract read
PubMed Publisher
In one paragraph

Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03494543 completednot on this map

Endoscopic Papillectomy for Ampullary Adenomas: an Italian Single Centre Experience

TypeobservationalSponsorAzienda USL Reggio Emilia - IRCCSRan2005 to 2017Enrolled62ConditionsAmpullary Adenoma, Familial Adenomatous PolyposisArmsEndoscopic Papillectomy
NCT05690412 unknown statusnot on this mapstarted 2022, after this paper: background citation

Efficacy and Safety of Endoscopic Papillectomy in the Treatment of Ampullary Neoplasms: a Multicenter, Retrospective, Nationwide Study.

TypeobservationalSponsorAzienda Unità Sanitaria Locale della RomagnaRan2022 to 2023Enrolled400ConditionsAmpullary Adenoma, Ampulla of Vater Adenoma, Ampullary Cancer, Ampulla of Vater CancerArmsEndoscopic Papillectomy
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Paolo CecinatoUnit of Gastroenterology and Digestive Endoscopy, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy. paolo.cecinato@ausl.re.it.ORCID 0000-0002-1870-5952
Francesca ParmeggianiUnit of Gastroenterology and Digestive Endoscopy, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.
Luca BragliaResearch and Statistics Infrastructure, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
Gabriele CarlinfanteUnit of Pathology, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
Ramona ZecchiniUnit of Gastroenterology and Digestive Endoscopy, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.
Francesco DecembrinoUnit of Gastroenterology and Digestive Endoscopy, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.
Veronica IoriUnit of Gastroenterology and Digestive Endoscopy, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.
Giuliana SereniUnit of Gastroenterology and Digestive Endoscopy, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.
Cristiana TioliUnit of Gastroenterology and Digestive Endoscopy, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.
Maurizio CavinaUnit of Gastroenterology and Digestive Endoscopy, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.
Lorenzo CamelliniUnit of Gastroenterology, ASL 5 Spezzino, La Spezia, Italy.
Francesco AzzoliniDivision of Gastroenterology and Gastrointestinal Endoscopy, Vita Salute San Raffaele University, Milan, Italy.
Maurizio Ponz de LeonDiagnostic Medicine Department, Clinic and Public Health, University of Modena and Reggio Emilia, Modena, Italy.
Romano SassatelliUnit of Gastroenterology and Digestive Endoscopy, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.
Azienda Sanitaria Unità Locale di Reggio Emilia · ITUniversity of Modena and Reggio Emilia · ITVita-Salute San Raffaele University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAmpullary adenomas are rare and potentially malignant. Surgery was the standard treatment but endoscopic papillectomy (EP) is a possible alternative.

aimWe retrospectively evaluated the principal clinical outcomes of EP in all patients referred to our unit also dividing sporadic ampullary adenoma (SAA) from familial adenomatous polyposis (FAP)-associated adenomas.

methodsAll consecutive patients who underwent endoscopic papillectomy because of ampullary adenoma were considered. The primary outcome was the technical success of EP. Secondary outcomes included the number of procedures, the adverse event rate, the recurrence rate, the concordance of histology pre- and post-EP, and the evaluation of factors related to technical success.

resultsBetween January 2001 and December 2015, sixty-two patients were included (21 FAP and 41 SAA). Technical success was achieved in 75.8% and was different in the two groups (FAP 95.2%, SAA 65.8%, p 0.025). Intraductal invasion was negatively associated with technical success (41.7% vs. 84.0%; p 0.005). The intestinal subtype was predictive of success (79.7% vs. 0%; p 0.012) as well as en bloc resection (90.3% vs. 61.3%; p 0.016). Adverse events were reported in 14 patients (22.6%).

conclusionsEP is an effective and safe procedure and is a viable alternative to surgery.

trial registrationClinicalTrials.gov Identifier: NCT03494543.

Indexed as

Adenomatous Polyposis ColiAmpulla of VaterCommon Bile Duct NeoplasmsHumansNeoplasm Recurrence, LocalRetrospective StudiesTreatment OutcomeAmpullary adenomasAmpullary carcinomaEndoscopic papillectomyFamilial adenomatous polyposis

Identifiers

PMID31898110
OpenAlexW2997381701

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.