Evidence map›Paper›PMID 31898046›Full record

ArticleObesity surgery2020

A Genetic Risk Score for the Estimation of Weight Loss After Bariatric Surgery.

E A Katsareli, C Amerikanou, K Rouskas, A Dimopoulos, T Diamantis, A Alexandrou, J Griniatsos, S Bourgeois, E Dermitzakis, J Ragoussis and 2 more

Abstract read
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In one paragraph

Article in Obesity surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

E A KatsareliHarokopio University of Athens, Department of Nutrition and Dietetics, Athens, Greece.
C AmerikanouHarokopio University of Athens, Department of Nutrition and Dietetics, Athens, Greece.
K RouskasBiomedical Sciences Research Center Al. Fleming, 16672, Vari, Greece.
A DimopoulosHellenic Naval Academy, Hatzikyriakou Ave., 18539, Piraeus, Greece.
T DiamantisDepartment of Surgery, National and Kapodistrian University of Athens, Medical School, Laiko Hospital, Agiou Thoma 17str, GR 115-27, Athens, Greece.
A AlexandrouDepartment of Surgery, National and Kapodistrian University of Athens, Medical School, Laiko Hospital, Agiou Thoma 17str, GR 115-27, Athens, Greece.
J GriniatsosDepartment of Surgery, National and Kapodistrian University of Athens, Medical School, Laiko Hospital, Agiou Thoma 17str, GR 115-27, Athens, Greece.
S BourgeoisThe William Harvey Research Institute - Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.
E DermitzakisDepartment of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland.
J RagoussisMcGill University Genome Centre and Department of Human Genetics, McGill University, Montréal, Quebec, Canada.
A S DimasBiomedical Sciences Research Center Al. Fleming, 16672, Vari, Greece.
G V DedoussisHarokopio University of Athens, Department of Nutrition and Dietetics, Athens, Greece. dedousi@hua.gr.ORCID 0000-0002-7798-6221

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) are the most frequent bariatric surgery procedures worldwide. In this prospective study, we examined the association of a genetic risk score (GRS) with loss of excess weight after bariatric surgery.

methodsA total of forty-seven morbidly obese Greek patients who underwent SG (81%) or RYGB were recruited, followed up for 2 years and genotyped. Weight loss after surgery was reported as the percentage of excess weight that was lost (%EWL) at 12 and 24 months after surgery. A GRS was constructed based on previously BMI- and WHR-related single nucleotide polymorphisms (SNPs) that were found significantly correlated with weight loss after bariatric surgery in our population. The level of post-surgery %EWL after 12 and 24 months was estimated through two multiple linear regression models that considered the effects of relevant genetic risk variants.

resultsThe first proposed model suggested that the predictor variables of GRS, age, and BMI had a significant effect on %EWL12m. GRS was significantly associated with %EWL12m, indicating a 4.618% decrease of %EWL12m per score unit. The second model indicated a positive correlation between %EWL24m and %EWL12m, suggesting that while post-surgery weight loss increased during the first 12 months, an increase was expected in the next 12 months as well. GRS was also significantly associated with %EWL24m, indicating approximately 3% decrease of %EWL24m per score unit.

conclusionGRS can be used in the future together with other preoperative parameters in order to predict the outcome of bariatric surgery.

Indexed as

Bariatric SurgeryGastric BypassObesity, MorbidGastrectomyHumansProspective StudiesRetrospective StudiesRisk FactorsTreatment OutcomeWeight Loss%EWLGenetic risk scoreMultiple linear regressionOne-way ANOVARoux-en Y gastric bypassSleeve gastrectomy

Identifiers

PMID31898046

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.