Evidence map›Paper›PMID 31897996›Full record

ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2021

Changes in microarchitecture of atherosclerotic calcification assessed by

Jeffrey J Hsu, Felicia Fong, Radha Patel, Rong Qiao, Karen Lo, Akrivoula Soundia, Chih-Chiang Chang, Victoria Le, Chi-Hong Tseng, Linda L Demer and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Preclinical techniques to investigate exercise training in vascular pathophysiology.American journal of physiology. Heart and circulatory physiology · 2021
    Pooled it
  2. Article
  3. Considerations in the Use of Mouse Models of Vascular and Valvular Calcification.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Effects of LP533401 on vascular and bone calcification in hyperlipidemic mice.Biochemical and biophysical research communications · 2024
    Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review of cardiovascular imaging in the Journal of Nuclear Cardiology 2022: positron emission tomography, computed tomography, and magnetic resonance.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Review
  15. Review
  16. Article
  17. Review
  18. Coronary artery calcification: More than meets the eye.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Jeffrey J Hsu *Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Felicia Fong *Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Radha PatelDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Rong QiaoDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Karen LoDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Akrivoula SoundiaSchool of Dentistry, University of California, Los Angeles, Los Angeles, CA, USA.
Chih-Chiang ChangDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA.
Victoria LeDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Chi-Hong TsengDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Linda L DemerDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Yin TintutDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. ytintut@mednet.ucla.edu.
University of California, Los Angeles · US

Funding

UCLA OLDER AMERICANS INDEPENDENCE CENTERP30AG028748 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MOORE, ALISON AHERN · 2006 to 2017
$9.8M
CARDIOVASCULAR SCIENTIST TRAINING PROGRAMT32HL007895 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SHIVKUMAR, KALYANAM, WATSON, KAROL E · 1998 to 2023
$9.2M
Serotonin receptor contribution to inflammation-induced calcific aortic valve diseaseR01HL137647 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DEMER, LINDA L., TINTUT, YIN · 2019 to 2022
$1.6M
Mechanisms of intermittent parathyroid hormone effects on calcific aortic diseaseR01HL121019 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DEMER, LINDA L., TINTUT, YIN · 2015 to 2018
$1.5M
Does aging transform calcific vasculopathy into a plaque stabilizing process?R21AG061586 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DEMER, LINDA L., TINTUT, YIN · 2019 to 2020
$429k
NHLBI NIH HHS R01 HL121019NHLBI NIH HHS R01 HL137647NHLBI NIH HHS T32 HL007895NIA NIH HHS P30 AG028748NIA NIH HHS R21 AG061586
6 · The paper itself

Abstract

backgroundDespite the association of physical activity with improved cardiovascular outcomes and the association of high coronary artery calcification (CAC) scores with poor prognosis, elite endurance athletes have increased CAC. Yet, they nevertheless have better cardiovascular survival. We hypothesized that exercise may transform vascular calcium deposits to a more stable morphology.

methodsTo test this, hyperlipidemic mice (Apoe

resultsResults showed that, while aortic calcification progressed similarly in both groups based on µCT, the fold change in

conclusionThese findings suggest that weeks-long progressive exercise alters the microarchitecture of atherosclerotic calcium deposits by reducing mineral surface growth, potentially favoring plaque stability.

Indexed as

AnimalsCalcification, PhysiologicDisease Models, AnimalFluorodeoxyglucose F18HyperlipidemiasMicePhysical Conditioning, AnimalPlaque, AtheroscleroticPositron Emission Tomography Computed TomographyRadiopharmaceuticalsFluorodeoxyglucose F18Radiopharmaceuticals18F-NaF PET/CT imagingaorticcalcificationhyperlipidemiamicroarchitecturePTHTreadmill exercise

Identifiers

PMID31897996
PMCPMC7329622
OpenAlexW2997667836

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.