Evidence map›Paper›PMID 31897976›Full record

ArticleJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology2020

The Protective Effects of Up-Regulating Prostacyclin Biosynthesis on Neuron Survival in Hippocampus.

Qing-Lan Ling, Hironari Akasaka, Chang Chen, Colin N Haile, Kevin Winoske, Ke-He Ruan

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 63% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Qing-Lan LingThe Center for Experimental Therapeutics and Pharmacoinformatics, Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Health and Biomedical Sciences Building 2, 4849 Calhoun Road, Room 3044, Houston, TX, 77204-5037, USA.
Hironari AkasakaThe Center for Experimental Therapeutics and Pharmacoinformatics, Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Health and Biomedical Sciences Building 2, 4849 Calhoun Road, Room 3044, Houston, TX, 77204-5037, USA.
Chang ChenThe Center for Experimental Therapeutics and Pharmacoinformatics, Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Health and Biomedical Sciences Building 2, 4849 Calhoun Road, Room 3044, Houston, TX, 77204-5037, USA.
Colin N HaileUniversity of Houston Animal Behavior Core Facility, Texas Institute for Measurement, Evaluation and Statistics (TIMES), Department of Psychology, University of Houston, Houston, TX, 77204, USA.
Kevin WinoskeUniversity of Houston Animal Behavior Core Facility, Texas Institute for Measurement, Evaluation and Statistics (TIMES), Department of Psychology, University of Houston, Houston, TX, 77204, USA.
Ke-He RuanThe Center for Experimental Therapeutics and Pharmacoinformatics, Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Health and Biomedical Sciences Building 2, 4849 Calhoun Road, Room 3044, Houston, TX, 77204-5037, USA. kruan@central.uh.edu.
University of Houston · US

Funding

Prostaglandin I synthase, Thromboxane A synthase & Prostaglandin E synthaseR01HL056712 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI RUAN, KE-HE · 2000 to 2009
$2.3M
NHLBI NIH HHS R01 HL056712NIH HHS R01 HL79389NIH HHS RO1 HL56712
6 · The paper itself

Abstract

Cellular arachidonic acid (AA), an unsaturated fatty acid found ubiquitously in plasma membranes, is metabolized to different prostanoids, such as prostacyclin (PGI

Indexed as

AnimalsCell LineCell SurvivalEpoprostenolHippocampusIloprostMaleMaze LearningMiceMice, TransgenicNeuronsNeuroprotective AgentsUp-RegulationEpoprostenolIloprostNeuroprotective AgentsCyclooxygenaseHippocampusNeurodegenerationProstacyclinProstaglandin E2Prostaglandin I2Transgenic mouse

Identifiers

PMID31897976
OpenAlexW2998229800

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.