ArticleFish physiology and biochemistry2020
The effects of quercetin on immunity, antioxidant indices, and disease resistance in zebrafish (Danio rerio).
Article in Fish physiology and biochemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 79 citations in OpenAlex.
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- Mitigation Exposed to Acute Cadmium Stress in Nile Tilapia by Dietary Quercetin: Exploring the Growth Performance, Intestinal Health, Stress Biomarkers, and Immune Responses.Biological trace element research · 2026Article
- Quercetin as a Nutritional Intervention: Enhancing Growth, Metabolism, and Immune Gene Modulation inACS omega · 2025Article
- Cyrtocarpa edulis fruit and its immunostimulant effect on Almaco Jack Seriola rivoliana: in vitro, in vivo and ex vivo studies.Veterinary research communications · 2024Article
- Effect ofAnimals : an open access journal from MDPI · 2024Article
- Oral administration of a new copper (I) complex with coumarin as ligand: modulation of the immune response and the composition of the intestinal microbiota inFrontiers in chemistry · 2024Article
- Zebrafish Model Insights into Mediterranean Diet Liquids: Olive Oil and Wine.Antioxidants (Basel, Switzerland) · 2023Review
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- Regulation of Host Defense Peptide Synthesis by Polyphenols.Antibiotics (Basel, Switzerland) · 2023Review
- Feruloyl oligosaccharides, isolated from bacterial fermented wheat bran, exhibit antioxidant effects in IPEC-J2 cells and zebrafish model.Food science & nutrition · 2023Article
- Quercetin Application for Common Carp (Aquaculture nutrition · 2023Article
- Protective Effects of Combined Utilization of Quercetin and Florfenicol on Acute Hepatopancreatic Necrosis Syndrome InfectedAntibiotics (Basel, Switzerland) · 2022Article
- Ameliorative Effect of Quercetin against Abamectin-Induced Hemato-Biochemical Alterations and Hepatorenal Oxidative Damage in Nile Tilapia,Animals : an open access journal from MDPI · 2022Article
- Synergistic Effect of Quercetin on Antibacterial Activity of Florfenicol AgainstAntibiotics (Basel, Switzerland) · 2022Article
- Phytocompounds as an Alternative Antimicrobial Approach in Aquaculture.Antibiotics (Basel, Switzerland) · 2022Review
- A potential role of nettle (Urtica dioica) extract on growth, biochemical changes and reproductive performance of convict cichlid (Amatitlania nigrofasciata).Fish physiology and biochemistry · 2022Article
- Oregano (Animals : an open access journal from MDPI · 2021Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The main purpose of this study was to evaluate the immunity, antioxidant indices, and disease resistance of quercetin in zebrafish (Danio rerio). A total of 630 fish were assigned to 21 tanks with 30 fish/tank, and they were exposed to 0, 0.01, 0.1, 1, 10, 100, and 1000 μg/L quercetin, respectively, for 56 days. Results indicated that the immune indices including acid phosphatase (ACP), myeloperoxidase (MPO), lysozyme activities, and Complement 3 (C3), C4, IgM contents were significantly higher in 1 μg/L quercetin group than these parameters in the control group (P < 0.05). TNF-α and IL-8 mRNA expressions significantly decreased as the levels of quercetin increased up to 1 μg/L and increased thereafter (P < 0.05). 1 and 10 μg/L quercetin groups showed significantly lower TNF-α and IL-8 mRNA levels than the quercetin-free group. Transforming growth factor-β and IL-10 mRNA levels showed an obviously opposite trend with TNF-α expression. The SOD, GPX, CAT, T-AOC activities, and SOD and GPX gene expression in the liver were enhanced with increasing quercetin up to 1 μg/L, and decreased thereafter. MDA contents were affected by quercetin, in which 1 and 10 μg/L quercetin had a significantly lower level than that of the control group (P < 0.05). Defensin and Leap-II mRNA expression in the liver were the highest for fish exposed to 1 μg/L quercetin. The fish that exposed to 1 μg/L quercetin also showed a significantly higher survival rate than these of fish exposed to 0, 0.01, and 1000 μg/L quercetin (P < 0.05). In conclusion, the optimal level of quercetin promotes immunostimulant properties, antioxidant indices, and disease resistance of zebrafish.
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