ArticleParasitology research2020
First report of the isolation and phylogenetic characterization of equine Setaria digitata from India based on mitochondrial COI, 12S rDNA, and nuclear ITS2 sequence data.
Article in Parasitology research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 14 citations in OpenAlex.
- Microfilarial morphometry and molecular characterization ofCurrent research in parasitology & vector-borne diseases · 2026Article
- Unraveling the morphological and molecular profile of Setaria digitata in Aceh cattle.Open veterinary journal · 2025Article
- Zoonotic filariasis and its public health significance: a comprehensive literature review.Frontiers in microbiology · 2025Review
- Molecular identification and genetic variability of equine and bovine ocular setariasis in india: molecular profiling by mitochondrial genes.Molecular biology reports · 2024Article
- Development and validation of a long-read metabarcoding platform for the detection of filarial worm pathogens of animals and humans.BMC microbiology · 2024Article
- Emergent and Neglected Equine Filariosis in Egypt: Species Diversity and Host Immune Response.Pathogens (Basel, Switzerland) · 2022Article
- Multiple vector-borne pathogens of domestic animals in Egypt.PLoS neglected tropical diseases · 2021Article
- First report of molecular and phylogenetic analysis of Physaloptera praeputialis in naturally infected stray cats from India.Parasitology research · 2021Article
- First Molecular Confirmation of Equine OcularVeterinary sciences · 2021Article
- Phylogenetic characterization of Setaria equina and its association with other filarids.Parasitology research · 2020Article
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6 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Equine ocular setariasis arising mainly from ectopic infestation of Setaria digitata is a common vision impairing ophthalmic disease in India, and the identification of this filarial nematode is based solely on morphology. However, morphological characters alone are inadequate to detect and differentiate S. digitata from its congeners. The present communication reports the first phylogenetic characterization of equine S. digitata from India based on sequences derived from the mitochondrial cytochrome c oxidase subunit 1 (COI), the mitochondrial small subunit ribosomal DNA (12S rDNA), and the nuclear internal transcribed spacer 2 (ITS2). Three isolates were characterized for each gene, and respective sequences were submitted to NCBI database (MN078131, MN078132, and MN095798). The sequences were also compared with the other related sequences available from PubMed around the globe, and phylogenetic analysis was carried out in conjunction with nucleotide homologies. There was no intraspecific variation among the Indian isolates. The phylogenetic analysis of S. digitata, inferred from these genes, showed that the isolate sequences obtained from different host species created a separate monophyletic clade within the genus Setaria with minor sequence variations revealing similar molecular characteristics of S. digitata isolates throughout the globe. In addition, the studied Indian isolates were found closer to Sri Lankan isolates. The S. digitata and S. labiatopapillosa appeared as sister species.
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