Evidence map›Paper›PMID 31897733›Full record

ArticleMikrochimica acta2020

A poly(acrylic acid)-modified copper-organic framework for electrochemical determination of vancomycin.

Atal A S Gill, Sima Singh, Nikhil Agrawal, Zondi Nate, Tirivashe E Chiwunze, Neeta Bachheti Thapliyal, Ruchika Chauhan, Rajshekhar Karpoormath

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Article in Mikrochimica acta, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 41 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Atal A S GillDepartment of Pharmaceutical Chemistry, College of Health Sciences, University of KwaZulu Natal, Durban, 4000, South Africa.
Sima SinghDepartment of Pharmaceutical Chemistry, College of Health Sciences, University of KwaZulu Natal, Durban, 4000, South Africa.
Nikhil AgrawalDepartment of Pharmaceutical Chemistry, College of Health Sciences, University of KwaZulu Natal, Durban, 4000, South Africa.
Zondi NateDepartment of Pharmaceutical Chemistry, College of Health Sciences, University of KwaZulu Natal, Durban, 4000, South Africa.
Tirivashe E ChiwunzeDepartment of Pharmaceutical Chemistry, College of Health Sciences, University of KwaZulu Natal, Durban, 4000, South Africa.
Neeta Bachheti ThapliyalDepartment of Pharmaceutical Chemistry, College of Health Sciences, University of KwaZulu Natal, Durban, 4000, South Africa.
Ruchika ChauhanDepartment of Pharmaceutical Chemistry, College of Health Sciences, University of KwaZulu Natal, Durban, 4000, South Africa.
Rajshekhar KarpoormathDepartment of Pharmaceutical Chemistry, College of Health Sciences, University of KwaZulu Natal, Durban, 4000, South Africa. karpoormath@ukzn.ac.za.ORCID 0000-0002-1247-5754
University of KwaZulu-Natal · ZA

Funding

National Research Foundation 103728National Research Foundation 112079
6 · The paper itself

Abstract

A copper(II) benzene-1,3,5-tricarboxylate (BTC) metal-organic framework (MOF) was modified with poly(acrylic acid) (PAA) and then used in an electrochemical sensor for vancomycin. The MOF, synthesized via a single-pot method, has enhanced solubility and dispersibility in water as compared to HKUST-1 but without compromising its crystallinity and porosity. The MOF was placed on a glassy carbon electrode (GCE) where it shows enhanced electrocatalytic properties. This is assumed to be due to the presence of the poly(acrylic acid) that forms a network between various HKUST-1 crystals through dimer formation between the carboxy groups of BTC and PAA. This also led to better dispersion of the MOF and to improved interaction between MOF and vancomycin. The structural, spectral and electrochemical properties of the MOFs and their vancomycin complexes was characterized. The modified GCE is shown to be a viable tool for electrochemical determination (best at a working potential of 784 mV vs. Ag/AgCl) of the antibiotic vancomycin in spiked urine and serum samples. Response is linear in the 1-500 nM vancomycin concentration range, and the detection limit is 1 nM, with a relative standard deviation of ±4.3%. Graphical abstractSchematic representation of a method for determination of vancomycin. Poly(acrylic acid) modified HKUST-1 (P-HKUST-1) forms a complex with vancomycin [Van-P-HKUST-1] which is coated over glassy carbon electrode (GCE). The decrease in peak current is recorded as response to vancomycin via cyclic voltammetry.

Indexed as

Acrylic ResinsCarbonCopperElectrochemical TechniquesElectrodesMetal-Organic FrameworksSolubilityVancomycinAcrylic Resinsbis(1,3,5-benzenetricarboxylate)tricopper(II)Carboncarbopol 940CopperMetal-Organic FrameworksVancomycinCyclic voltammetryDifferential pulse voltammetryDrug deliveryElectrical impedance spectroscopyMethicillin resistant Staphylococcus aureusRedox active

Identifiers

PMID31897733
OpenAlexW2998355054

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.