ReviewPediatric nephrology (Berlin, Germany)2020
The brain in pediatric chronic kidney disease-the intersection of cognition, neuroimaging, and clinical biomarkers.
Review in Pediatric nephrology (Berlin, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Neuron-specific enolase and brain-derived neurotrophic factor as developmental neurovascular markers in chronic kidney disease and kidney transplantation.Pediatric nephrology (Berlin, Germany) · 2026Article
- Adequacy of dialysis in children and adolescents: more than just Kt/V.Pediatric nephrology (Berlin, Germany) · 2026Review
- Beyond Kidney Function: A Neuro-Renal Perspective on Personalized Care in Pediatric Chronic Kidney Disease.Medical sciences (Basel, Switzerland) · 2026Review
- Neurocognitive and Motor Performance in Pediatric Kidney Transplant Recipients: A Cross-Sectional Controlled Study.Children (Basel, Switzerland) · 2026Article
- Associations Between Sickle Cell Disease, Pica, and Enuresis in Pediatric Neurodevelopmental Disorders.Medical sciences (Basel, Switzerland) · 2026Article
- Article
- Cognitive deterioration in patients undergoing hemodialysis: how variations in age influence the development of new mechanisms and treatment approaches?Frontiers in aging neuroscience · 2025Review
- Common mental health conditions and considerations in pediatric chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2024Review
- Socioeconomic Position and Health Among Children and Adolescents With CKD Across the Life-Course.Kidney international reports · 2024Review
- Role of primary care in enhancing continuity of care for adolescents and young adults with chronic kidney disease undergoing transition to adult health services.Pediatric nephrology (Berlin, Germany) · 2024Article
- Self-concept and academic achievement in children with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2024Article
- Daily practice evaluation of the paediatric set of a next-generation long-term haemodialysis machine.Pediatric nephrology (Berlin, Germany) · 2023Article
- Global and Regional White Matter Fractional Anisotropy in Children with Chronic Kidney Disease.The Journal of pediatrics · 2022Article
- Factors Affecting Neurocognitive Function in Children with Chronic Kidney Disease: A Systematic Review.International journal of nephrology and renovascular disease · 2022Review
- The pressure's on: understanding neurocognitive and psychological associations with pediatric hypertension to inform comprehensive care.Pediatric nephrology (Berlin, Germany) · 2021Review
- How FGF23 shapes multiple organs in chronic kidney disease.Molecular and cellular pediatrics · 2021Review
- Functional Magnetic Resonance Imaging Findings in Children and Adolescents With Chronic Kidney Disease: Preliminary Findings.Seminars in nephrology · 2021Review
- Neurocognition in Pediatric Chronic Kidney Disease: A Review of Data From the Chronic Kidney Disease in Children (CKiD) Study.Seminars in nephrology · 2021Review
- Magnetic Resonance Imaging in Childhood Primary Hypertension: Potential in the Study of Cognitive Outcomes.Hypertension (Dallas, Tex. : 1979) · 2021Review
- Not Just Small Adults: Considerations for Pediatric Chronic Kidney Disease.Indian journal of nephrologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Brain growth and development occur at peak rates in early childhood through adolescence, and for some children, this must happen in conjunction with chronic kidney disease (CKD), associated medical conditions, and their treatment(s). This review provides an overview of key findings to date on the topic of the brain in pediatric CKD. Here, we specifically address the topics of neuroimaging and cognition in pediatric CKD with consideration to biomarkers of disease progression that may impact cognition. Current cognitive data suggest that most children with mild to moderate CKD do not exhibit significant cognitive impairments, but, rather, the presence of somewhat lower intellectual abilities and subtle deficits in selected executive functions. Although promising, modern neuroimaging data remain inconclusive in linking cognitive findings to neuroimaging correlates in the pediatric CKD population. Certainly, it is important to note that even subtle cognitive concerns can present barriers to learning, social functioning, and overall quality of life if not appropriately recognized or addressed. Further longitudinal research utilizing concurrent and targeted cognitive and neuroimaging evaluations is warranted to better understand the impact of CKD progression on brain development and associated neurocognitive outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.