ArticleVirusdisease2019
Applicability of molecular assays for detection and typing of herpes simplex viruses in encephalitis cases.
Article in Virusdisease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Navigating herpes simplex encephalitis: Family medicine perspectives from Jharkhand, India.Journal of family medicine and primary care · 2024Article
- Application of Environment-Friendly Rhamnolipids against Transmission of Enveloped Viruses Like SARS-CoV2.Viruses · 2021Article
- In-vitro and in silico activity ofVirusdisease · 2020Article
- The Indian perspective of COVID-19 outbreak.Virusdisease · 2020Review
- Article
- Refractory Status Epilepticus Responsive to Electroacupuncture at Shuigou Acupoint: A Case Report.Frontiers in neurology · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Herpes simplex viruses (HSVs) cause a latent infection in humans which is mainly associated with characteristic cold sores or fever blisters and genital blisters. Large segments of the world population are suffering from the HSV infection and early diagnosis as well as treatments are needed to avoid further complications. HSV surveillance is very sparse, especially from developing countries including India. The aim of the present study is to develop and evaluate molecular assays for rapid detection and typing of HSV. In the present study, viral DNA was extracted from cerebro-spinal fluid from HSV suspected encephalitis patients. The conventional multiplex PCR for HSV-1 and HSV-2 was optimized and their comparative analysis was done with Real-Time qPCR for detection and typing of HSV. Out of 137 clinical samples, eleven samples (8.03%) were diagnosed as HSV positive by Real-Time qPCR while ten (7.3%) by conventional multiplex PCR which were further typed as subtyping HSV-1 (nine) and HSV-2 (two). Real-Time qPCR is highly sensitive and able to detect 9.4 × 10
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