Evidence map›Paper›PMID 31897411›Full record

ArticleOrthopaedic journal of sports medicine2019

Ultrastructural Assessment of the Anterolateral Ligament.

Andrea Redler, Selenia Miglietta, Edoardo Monaco, Roberto Matassa, Michela Relucenti, Matthew Daggett, Andrea Ferretti, Giuseppe Familiari

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Orthopaedic journal of sports medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Anatomy of the anterolateral ligament of the knee joint.World journal of clinical cases · 2022
    Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Characterization ofMicroorganisms · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Andrea RedlerOrthopaedic Unit and Kirk Kilgour Sports Injury Centre, S. Andrea Hospital, University of Rome Sapienza, Rome, Italy.
Selenia MigliettaDepartment of Anatomy, Histology, Forensic Medicine and Orthopaedics, University of Rome Sapienza, Rome, Italy.
Edoardo MonacoOrthopaedic Unit and Kirk Kilgour Sports Injury Centre, S. Andrea Hospital, University of Rome Sapienza, Rome, Italy.
Roberto MatassaDepartment of Anatomy, Histology, Forensic Medicine and Orthopaedics, University of Rome Sapienza, Rome, Italy.
Michela RelucentiDepartment of Anatomy, Histology, Forensic Medicine and Orthopaedics, University of Rome Sapienza, Rome, Italy.
Matthew DaggettKansas City University of Medicine and Biosciences, Kansas City, Missouri, USA.
Andrea FerrettiOrthopaedic Unit and Kirk Kilgour Sports Injury Centre, S. Andrea Hospital, University of Rome Sapienza, Rome, Italy.
Giuseppe FamiliariDepartment of Anatomy, Histology, Forensic Medicine and Orthopaedics, University of Rome Sapienza, Rome, Italy.
Kansas City University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe anterolateral ligament (ALL) has been identified as a structure on the lateral side of the knee, but debate exists regarding whether it is a capsular thickening or a ligament. HYPOTHESIS: A detailed ultrastructural characterization of the ALL and its ultrastructure collagen arrangement will reveal it more closely resembles ligamentous tissue than joint capsule. STUDY

designDescriptive laboratory study.

methodsEight paired knee samples from 4 fresh-frozen male cadavers were used for this study. Samples were harvested from the ALL, the joint capsule, and the medial collateral ligament (MCL). All samples were evaluated with light microscopy (LM), transmission electron microscopy (TEM), and variable pressure scanning electron microscopy (VP-SEM). With LM, the 3 tissues were analyzed and their morphology described. With TEM, the ultrastructure and collagen characteristics were quantified and compared among specimens. Then, the 3-dimensional characteristics were compared with VP-SEM.

resultsUltrastructure analysis demonstrated similar morphology between the ALL and MCL, with significant differences in these 2 structures as compared with the joint capsule. On LM, the ALL and MCL were characterized by the presence of a dense collagen fiber oriented in the longitudinal and transversal directions of the fiber bundles, while the joint capsule was found to have a more disorganized architecture. On TEM, the collagen fibers of the ALL and MCL demonstrated similar ultrastructural morphology, with both having collagen fibers in parallel, longitudinal alignment. A quantitative analysis was also performed, with the mean (± SD) diameter of fibrils in the ALL and MCL being 80 ± 2.66 nm and 150 ± 3.35 nm, respectively (all

conclusionThe ALL and MCL have comparable ultrastructures that are distinctly different from the joint capsule, as visualized on LM, TEM, and VP-SEM. CLINICAL RELEVANCE: The ALL should be considered a distinctive structure of the knee, although strictly connected to the surrounding capsule.

Indexed as

anterior cruciate ligamentanterolateral ligamentelectron microscopyultrastructure

Identifiers

PMID31897411
PMCPMC6920591
OpenAlexW2996055782

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.