Evidence map›Paper›PMID 31897093›Full record

ArticleExperimental and therapeutic medicine2020

miR-224-5p protects dental pulp stem cells from apoptosis by targeting Rac1.

Wenlan Qiao, Dong Li, Qing Shi, Huanhuan Wang, Hao Wang, Jing Guo

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental and therapeutic medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Wenlan QiaoShandong Provincial Key Laboratory of Oral Tissue Regeneration, Department of Orthodontics, School of Stomatology, Shandong University, Jinan, Shandong 250012, P.R. China.
Dong LiDepartment of Cryomedicine Laboratory, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China.
Qing ShiDepartment of Cryomedicine Laboratory, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China.
Huanhuan WangDepartment of Cryomedicine Laboratory, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China.
Hao WangDepartment of Cryomedicine Laboratory, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China.
Jing GuoShandong Provincial Key Laboratory of Oral Tissue Regeneration, Department of Orthodontics, School of Stomatology, Shandong University, Jinan, Shandong 250012, P.R. China.
Qilu Hospital of Shandong University · CNShandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dental pulp stem cells (DPSCs) are reported to be enriched in stem/progenitor cells, however to the best of our knowledge they have yet to be well documented and characterized. In the present study, in order to characterize DPSCs and the effect of microRNAs (miRs/miRNAs) on DPSC properties, a miRNA array was performed between dental periodontal ligament cells (DPLCs) and DPSCs. The results revealed that miR-224-5p (miR-224) was highly expressed in the DPSCs compared with that in the DPLCs. The transfection of DPSCs with an miR-224 inhibitor impaired cell viability. In addition, miR-224 inhibition significantly promoted cell apoptosis in DPSCscompared with the NC group.

Indexed as

apoptosisdental pulp stem cellmiR-224Rac1

Identifiers

PMID31897093
PMCPMC6923752
OpenAlexW2983012541

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.