Evidence map›Paper›PMID 31896932›Full record

ArticleInternational journal of tryptophan research : IJTR2019

Lipopolysaccharide Increases Cortical Kynurenic Acid and Deficits in Reference Memory in Mice.

Lee Peyton, Alfredo Oliveros, Maximilian Tufvesson-Alm, Lilly Schwieler, Phillip Starski, Göran Engberg, Sopie Erhardt, Doo-Sup Choi

Open access · goldAbstract read
In one paragraph

Article in International journal of tryptophan research : IJTR, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Lee PeytonDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.
Alfredo OliverosDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.
Maximilian Tufvesson-AlmDepartment of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden.
Lilly SchwielerDepartment of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden.
Phillip StarskiNeuroscience Program, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.
Göran EngbergDepartment of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden.
Sopie ErhardtDepartment of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden.ORCID https://orcid.org/0000-0001-7359-5250
Doo-Sup ChoiDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.ORCID https://orcid.org/0000-0002-6796-9938
Karolinska Institutet · SEMayo Clinic · US

Funding

Predoctoral Training Program in Molecular PharmacologyT32GM072474 · NIGMS · MAYO CLINIC ROCHESTER · PI KARNITZ, LARRY M · 2005 to 2020
$2.4M
NIGMS NIH HHS T32 GM072474
6 · The paper itself

Abstract

Kynurenic acid (KYNA), a glial-derived metabolite of tryptophan metabolism, is an antagonist of the alpha 7 nicotinic acetylcholine receptor and the glycine-binding site of

Indexed as

Kynurenic-acidlipopolysaccharidemedial-prefrontal cortexreference memoryspatial memory

Identifiers

PMID31896932
PMCPMC6920585
OpenAlexW2996426837

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.