Evidence map›Paper›PMID 31896840›Full record

ArticleIndian journal of dermatology

Increased Plasma Levels of S100A8, S100A9, and S100A12 in Chronic Spontaneous Urticaria.

Qiong-Yan Zhou, Wei Lin, Xiao-Xia Zhu, Su-Ling Xu, Meng-Xia Ying, Lei Shi, Bing-Jiang Lin

Open access · diamondAbstract read
In one paragraph

Article in Indian journal of dermatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Qiong-Yan ZhouDepartment of Dermatology, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, Zhejiang, China.
Wei LinDepartment of Pharmacy, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, Zhejiang, China.
Xiao-Xia ZhuDepartment of Dermatology, Ningbo First Hospital, Ningbo, Zhejiang, China.
Su-Ling XuDepartment of Dermatology, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, Zhejiang, China.
Meng-Xia YingDepartment of Dermatology, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, Zhejiang, China.
Lei ShiDepartment of Dermatology, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, Zhejiang, China.
Bing-Jiang LinDepartment of Dermatology, Ningbo First Hospital, Ningbo, Zhejiang, China.
Ningbo University · CNNingbo First Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic spontaneous urticaria (CSU) is a skin disorder with an important immunologic profile. S100A8, S100A9, and S100A12 are the members of S100 family that have been reported to play important role in autoimmune diseases, but the characteristics of these three S100 members have not been defined in CSU.

aimsThis study was performed to investigate the levels of these three S100s in patients with CSU and to study whether they were associated with the severity and clinical characteristics of CSU. MATERIALS AND

methodsThe levels of plasma S100A8, S100A9, and S100A12 were measured in 51 CSU patients and 20 healthy controls using enzyme linked immunosorbent assay kits. The values in the patient group and that of the healthy controls were statistically compared. The relationships between the different markers were evaluated by correlation analysis.

resultsThe plasma levels of S100A8, S100A9, and S100A12 were significantly higher in CSU patients than those in controls. Interestingly, the level of S100A12 was significantly correlated with S100A8 and S100A9 in CSU patients (

conclusionsPlasma S100A8, S100A9, and S100A12 levels were elevated in CSU patients. They might be useful biomarkers of CSU, with the potential role in the pathogenesis of CSU.

Indexed as

Chronic spontaneous urticariaS100A12S100A8S100A9

Identifiers

PMID31896840
PMCPMC6862366
OpenAlexW2984191231

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.