ArticleThe ISME journal2020
Novel syntrophic bacteria in full-scale anaerobic digesters revealed by genome-centric metatranscriptomics.
Article in The ISME journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 190 citations in OpenAlex.
- Metagenomic and cultivation-based description of a syntrophic butyrate-oxidizing bacterium from a thermophilic and high-ammonia biogas process.BMC microbiology · 2026Article
- A statistical framework for identifying microbial indicators of ammonia-induced process instability in food waste anaerobic digestion.Bioprocess and biosystems engineering · 2026Article
- Uncovering syntrophic potential from genome-resolved metagenomics of suspended and granular anaerobic digestion sludges.FEMS microbiology ecology · 2026Article
- Identification of a highly expressed gene cluster likely coding for benzene activation enzymes in a methanogenic enrichment culture.Applied and environmental microbiology · 2026Article
- Lithosyntrophy: Obligate syntrophy in a phosphite-oxidizing, methanogenic culture.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Bacteria and phage consortia modulate cecal SCFA production and host metabolism to enhance feed efficiency in ducks.Microbiome · 2026Article
- Phylum-wide propionate degradation and its potential connection to poly-gamma-glutamate biosynthesis in Candidatus Cloacimonadota phylum.The ISME journal · 2026Article
- Activity-targeted metaproteomics uncovers rare syntrophic bacteria central to anaerobic community metabolism.Nature microbiology · 2025Article
- Anaerobic Digestion Performance and Microbial Community Structures in a Pilot-Scale Up-Flow Anaerobic Sludge Blanket (UASB) Treating Distillery Wastewater.Water environment research : a research publication of the Water Environment Federation · 2025Article
- A country-wide survey into the composition and transformation of short-chain organic acids in anaerobic sludge digesters at wastewater treatment plants in Denmark.Scientific reports · 2025Article
- Disruption-induced changes in syntrophic propionate and acetate oxidation: flocculation, cell proximity, and microbial activity.Biotechnology for biofuels and bioproducts · 2025Article
- Environmental instability reduces shock resistance by enriching specialist taxa with distinct two component regulatory systems.NPJ biofilms and microbiomes · 2025Article
- Metagenomics Disentangles Differential Resistome Traits and Risks in Full-Scale Anaerobic Digestion Plants under Ambient, Mesophilic, and Thermophilic Conditions.ACS environmental Au · 2025Article
- Anaerobic digestion of microalgae: microbial response and recovery after organic loading disturbances.mSystems · 2025Article
- Habitat-specificity in SAR11 is associated with a few genes under high selection.The ISME journal · 2025Article
- Microbiome as an endocrine organ and its relationship with eye diseases: Effective factors and new targeted approaches.World journal of gastrointestinal pathophysiology · 2024Review
- Optimizing anaerobic digestion: Benefits of mild temperature transition from thermophilic to mesophilic conditions.Environmental science and ecotechnology · 2024Article
- Pre-treatment with Trichoderma viride: Towards a better understanding of its consequences for anaerobic digestion.Environmental microbiology reports · 2024Article
- Blood Microbiota and Its Products: Mechanisms of Interference with Host Cells and Clinical Outcomes.Hematology reports · 2024Review
- Metatranscriptomics-guided genome-scale metabolic reconstruction reveals the carbon flux and trophic interaction in methanogenic communities.Microbiome · 2024Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Short-chain fatty acid (SCFA) degradation is an important process in methanogenic ecosystems, and is usually catalyzed by SCFA-oxidizing bacteria in syntrophy with methanogens. Current knowledge of this functional guild is mainly based on isolates or enrichment cultures, but these may not reflect the true diversity and in situ activities of the syntrophs predominating in full-scale systems. Here we obtained 182 medium to high quality metagenome-assembled genomes (MAGs) from the microbiome of two full-scale anaerobic digesters. The transcriptomic response of individual MAG was studied after stimulation with low concentrations of acetate, propionate, or butyrate, separately. The most pronounced response to butyrate was observed for two MAGs of the recently described genus Candidatus Phosphitivorax (phylum Desulfobacterota), expressing a butyrate beta-oxidation pathway. For propionate, the largest response was observed for an MAG of a novel genus in the family Pelotomaculaceae, transcribing a methylmalonyl-CoA pathway. All three species were common in anaerobic digesters at Danish wastewater treatment plants as shown by amplicon analysis, and this is the first time their syntrophic features involved in SCFA oxidation were revealed with transcriptomic evidence. Further, they also possessed unique genomic features undescribed in well-characterized syntrophs, including the metabolic pathways for phosphite oxidation, nitrite and sulfate reduction.
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