ArticleThe ISME journal2020
Mycobacterium bovis uses the ESX-1 Type VII secretion system to escape predation by the soil-dwelling amoeba Dictyostelium discoideum.
Article in The ISME journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Bacterial expression of human small GTPases induces stochastic predatory responses and motility interference in Physarum polycephalum.PloS one · 2026Article
- A novel influenza vector-based vaccine expressing ESAT-6 and TB10.4 confers immunity and protection againstVeterinary world · 2025Article
- Review
- Exploring host-pathogen interactions in the Dictyostelium discoideum-Mycobacterium marinum infection model of tuberculosis.Disease models & mechanisms · 2024Review
- Temporal genome-wide fitness analysis ofmSystems · 2024Article
- Predation-resistant Pseudomonas bacteria engage in symbiont-like behavior with the social amoeba Dictyostelium discoideum.The ISME journal · 2023Article
- Exploring the role of wastewater-based epidemiology in understanding tuberculosis burdens in Africa.Environmental research · 2023Article
- Environmental stress promotes the persistence of facultative bacterial symbionts in amoebae.Ecology and evolution · 2023Article
- Article
- Article
- The source and fate of Mycobacterium tuberculosis complex in wastewater and possible routes of transmission.BMC public health · 2022Article
- Pathological, Histological, and Molecular Based Investigations Confirm NovelBioMed research international · 2022Article
- Microbial warfare in the wild-the impact of protists on the evolution and virulence of bacterial pathogens.International microbiology : the official journal of the Spanish Society for Microbiology · 2021Review
- The Ecology and Evolution of Amoeba-Bacterium Interactions.Applied and environmental microbiology · 2021Review
- Probing Differences in Gene Essentiality Between the Human and Animal Adapted Lineages of theFrontiers in veterinary science · 2021Article
- DoesVeterinary medicine international · 2021Review
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Authors and funding
9 authors.
Funding
Abstract
Mycobacterium bovis is the causative agent of bovine tuberculosis and the predominant cause of zoonotic tuberculosis in people. Bovine tuberculosis occurs in farmed cattle but also in a variety of wild animals, which form a reservoir of infection. Although direct transmission of tuberculosis occurs between mammals, the low frequency of contact between different host species and abundant shedding of bacilli by infected animals suggests an infectious route via environmental contamination. Other intracellular pathogens that transmit via the environment deploy strategies to survive or exploit predation by environmental amoebae. To explore if M. bovis has this capability, we investigated its interactions with the soil and dung-dwelling amoeba, Dictyostelium discoideum. We demonstrated that M. bovis evades phagocytosis and destruction by D. discoideum and actively transits through the amoeba using the ESX-1 Type VII Secretion System as part of a programme of mechanisms, many of which have been co-opted as virulence factors in the mammalian host. This capacity of M. bovis to utilise an environmental stage between mammalian hosts may enhance its transmissibility. In addition, our data provide molecular evidence to support an evolutionary role for amoebae as training grounds for the pathogenic M. tuberculosis complex.
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