Evidence map›Paper›PMID 31896761›Full record

ArticleMucosal immunology2020

IL-35 is critical in suppressing superantigenic Staphylococcus aureus-driven inflammatory Th17 responses in human nasopharynx-associated lymphoid tissue.

Rong Xu, Rebecca K Shears, Ravi Sharma, Madhan Krishna, Christopher Webb, Richard Ali, Xiaoqing Wei, Aras Kadioglu, Qibo Zhang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mucosal immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Rong XuDepartment of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool, UK.
Rebecca K ShearsDepartment of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool, UK.
Ravi SharmaENT Department, Alder Hey Children's Hospital, Liverpool, UK.
Madhan KrishnaENT Department, Alder Hey Children's Hospital, Liverpool, UK.
Christopher WebbENT Department, Royal Liverpool and Broadgreen University Hospitals, Liverpool, UK.
Richard AliInstitute of Tissue Engineering and Repair, School of Dentistry, College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK.
Xiaoqing WeiInstitute of Tissue Engineering and Repair, School of Dentistry, College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK.
Aras KadiogluDepartment of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool, UK.
Qibo ZhangDepartment of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool, UK. qibo.zhang@liv.ac.uk.ORCID http://orcid.org/0000-0003-0489-5086
University of Liverpool · GBCardiff University · GBRoyal Liverpool and Broadgreen University Hospital NHS Trust · GB

Funding

Medical Research Council MR/P011284/1
6 · The paper itself

Abstract

The human nasopharynx is frequently exposed to microbial pathogens, including superantigen-producing Staphylococcus aureus (SAg-Sau), which activates potent pro-inflammatory T cell responses. However, cellular mechanisms that control SAg-Sau-driven T cell activation are poorly understood. Using human nasopharynx-associated lymphoid tissue (NALT), we show that SAg-Sau drove a strong Th17 activation, which was associated with an impaired CD4

Indexed as

Antigens, BacterialCD4-Positive T-LymphocytesForkhead Transcription FactorsHumansInterleukin-10InterleukinsLymph NodesLymphoid TissueNasopharynxNuclear Receptor Subfamily 1, Group F, Member 3Palatine TonsilStaphylococcus aureusSuperantigensTh17 CellsT-Lymphocytes, RegulatoryAntigens, BacterialForkhead Transcription FactorsFOXP3 protein, humanIL10 protein, humanInterleukin-10interleukin-35, humanInterleukinsNuclear Receptor Subfamily 1, Group F, Member 3RORC protein, humanSuperantigens

Identifiers

PMID31896761
PMCPMC7181393
OpenAlexW2997014175

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.