ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
Threat Prediction from Schemas as a Source of Bias in Pain Perception.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Neural correlates of uncertainty processing: meta-analysis of fMRI studies.Frontiers in neuroscience · 2025Pooled it
- High-definition tDCS over primary motor cortex modulates brain signal variability and functional connectivity in episodic migraine.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Trial
- Functional Magnetic Resonance Imaging Signal Variability Is Associated With Neuromodulation in Fibromyalgia.Neuromodulation : journal of the International Neuromodulation Society · 2023Trial
- Effects of Self-Efficacy and Outcome Expectations on Motor Imagery-Induced Thermal and Mechanical Hypoalgesia: A Single-Blind Randomised Controlled Trial.International journal of environmental research and public health · 2022Trial
- Brain mechanisms of pain anticipation in chronic low back pain: Insights into phenotypical responses to mind-body therapy.The journal of pain · 2026Article
- Exploring the Influence of Testosterone on Pain Perception and Modulation Among Men with Low and Normal Testosterone Concentrations.Journal of pain research · 2026Article
- EEG Correlates of the Influence of Somatosensory Input, Expectations and Trait-Like Bias on Pain Perception.European journal of pain (London, England) · 2025Article
- Investigating the Influence of Experimentally Induced Secondary Hyperalgesia on Pain Prediction Error Encoding in Healthy Individuals: A Novel Virtual Reality Protocol.European journal of pain (London, England) · 2025Article
- Potential for the medial prefrontal cortex to link mentalizing and attachment schemas.Social cognitive and affective neuroscience · 2025Review
- Integration of Prior Expectations and Suppression of Prediction Errors During Expectancy-Induced Pain Modulation: The Influence of Anxiety and Pleasantness.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Shape deformations of the basal ganglia in patients with classical trigeminal neuralgia: a cross-sectional evaluation.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Symptoms reported by Canadians posted in Havana are linked with reduced white matter fibre density.Brain communications · 2022Article
- Structural and functional thalamocortical connectivity study in female fibromyalgia.Scientific reports · 2021Article
- Aberrant Brain Signal Variability and COMT Genotype in Chronic TMD Patients.Journal of dental research · 2021Article
- Differential alteration of fMRI signal variability in the ascending trigeminal somatosensory and pain modulatory pathways in migraine.The journal of headache and pain · 2021Article
- Article
- Beliefs about the body and pain: the critical role in musculoskeletal pain management.Brazilian journal of physical therapyReview
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our sensory impressions of pain are generally thought to represent the noxious properties of an agent but can be influenced by the predicted level of threat. Predictions can be sourced from higher-order cognitive processes, such as schemas, but the extent to which schemas can influence pain perception relative to bottom-up sensory inputs and the underlying neural underpinnings of such a phenomenon are unclear. Here, we investigate how threat predictions generated from learning a cognitive schema lead to inaccurate sensory impressions of the pain stimulus. Healthy male and female participants first detected a linear association between cue values and stimulus intensity and rated pain to reflect the linear schema when compared with uncued heat stimuli. The effect of bias on pain ratings was reduced when prediction errors (PEs) increased, but pain perception was only partially updated when measured against stepped increases in PEs. Cognitive, striatal, and sensory regions graded their responses to changes in predicted threat despite the PEs (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.