Evidence map›Paper›PMID 31896670›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020

Grafting Embryonic Raphe Neurons Reestablishes Serotonergic Regulation of Sympathetic Activity to Improve Cardiovascular Function after Spinal Cord Injury.

Shaoping Hou, Tatiana M Saltos, Eugene Mironets, Cameron T Trueblood, Theresa M Connors, Veronica J Tom

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 28 citations in OpenAlex.

  1. Regional Molecular Diversity in Chronic Spinal Cord Injury.Cellular and molecular neurobiology · 2026
    Article
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  8. Autonomic Dysreflexia in Spinal Cord Injury: Mechanisms and Prospective Therapeutic Targets.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024
    Review
  9. Article
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  11. Article
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  15. Article
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  18. Cell transplantation to repair the injured spinal cord.International review of neurobiology · 2022
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Shaoping HouMarion Murray Spinal Cord Research Center, Department of Neurobiology & Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129 vjt25@drexel.edu sh698@drexel.edu.ORCID 0000-0003-4936-4465
Tatiana M SaltosMarion Murray Spinal Cord Research Center, Department of Neurobiology & Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129.
Eugene MironetsMarion Murray Spinal Cord Research Center, Department of Neurobiology & Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129.ORCID 0000-0002-1081-8661
Cameron T TruebloodMarion Murray Spinal Cord Research Center, Department of Neurobiology & Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129.
Theresa M ConnorsMarion Murray Spinal Cord Research Center, Department of Neurobiology & Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129.
Veronica J TomMarion Murray Spinal Cord Research Center, Department of Neurobiology & Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129 vjt25@drexel.edu sh698@drexel.edu.ORCID 0000-0002-3369-7575
Drexel University · US

Funding

CENTER FOR NEUROANATOMY WITH NEUROTROPIC VIRUSES: COMPARATIVE MEDICINEP40RR018604 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STRICK, PETER · 2004 to 2011
$6.5M
Multipronged approach to promote functional axonal regeneration in the spinal cord after injuryR01NS085426 · NINDS · DREXEL UNIVERSITY · PI TOM, VERONICA JEAN · 2014 to 2024
$3.6M
Soluble TNFa in the development of autonomic dysreflexia after spinal cord injuryR01NS106908 · NINDS · DREXEL UNIVERSITY · PI BETHEA, JOHN ROLAND, TOM, VERONICA JEAN · 2018 to 2022
$2.9M
Spinal dopaminergic mechanisms regulating the micturition reflex after spinal cord injuryR01NS099076 · NINDS · DREXEL UNIVERSITY · PI HOU, SHAOPING · 2017 to 2021
$1.8M
NCRR NIH HHS P40 RR018604NINDS NIH HHS R01 NS085426NINDS NIH HHS R01 NS099076NINDS NIH HHS R01 NS106908
6 · The paper itself

Abstract

Cardiovascular dysfunction often occurs after high-level spinal cord injury. Disrupting supraspinal vasomotor pathways affects basal hemodynamics and contributes to the development of autonomic dysreflexia (AD). Transplantation of early-stage neurons to the injured cord may reconstruct the descending projections to enhance cardiovascular performance. To determine the specific role of reestablishing serotonergic regulation of hemodynamics, we implanted serotonergic (5-HT

Indexed as

AnimalsAutonomic DysreflexiaCardiovascular SystemEmbryonic Stem CellsFemaleHemodynamicsNeural Stem CellsRaphe NucleiRatsRats, Inbred F344Serotonergic NeuronsSpinal Cord InjuriesStem Cell TransplantationSympathetic Nervous Systemcell transplantationhemodynamicsspinal cord transectiontranssynaptic tracing

Identifiers

PMID31896670
PMCPMC7002146
OpenAlexW2997545102

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.