Evidence map›Paper›PMID 31896593›Full record

ArticleJournal of virology2020

Rotavirus Reprograms Multiple Interferon Receptors and Restricts Their Intestinal Antiviral and Inflammatory Functions.

Adrish Sen, Nima D Namsa, Ningguo Feng, Harry B Greenberg

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.3field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

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  7. Immunomodulatory Effects ofJournal of microbiology and biotechnology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Adrish SenDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA.
Nima D NamsaDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA.
Ningguo FengDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA.
Harry B GreenbergDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA hbgreen@stanford.edu.
VA Palo Alto Health Care System · USStanford University · US

Funding

VIRAL GASTROENTERITIS--BASIS OF PROTECTION AND VIRULENCER01AI021362 · NIAID · STANFORD UNIVERSITY · PI GREENBERG, HARRY BERNARD · 1989 to 2014
$5.4M
Regulation of Rotavirus Replication, Virulence, and Host Range Restriction by the Innate Immune SystemR01AI125249 · NIAID · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI GREENBERG, HARRY BERNARD · 2017 to 2021
$2.1M
Rotavirus: Studies of the Effectors and Mechanisms of Heterotypic Humoral Immunity in Human Intestinal Epithelial CellsI01BX000158 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI GREENBERG, HARRY BERNARD · 2011 to 2022
–
BLRD VA I01 BX000158NIAID NIH HHS R01 AI021362NIAID NIH HHS R01 AI125249
6 · The paper itself

Abstract

Rotaviruses (RV) cause acute severe diarrhea in the absence of substantial intestinal inflammation. They are also highly infectious in their homologous host species. The replication capacity of RV in the small bowel is substantially due to its ability to inhibit different types of interferons (IFNs). Here, we found that during RV infection

Indexed as

AnimalsCaspasesCytokinesHEK293 CellsHT29 CellsHumansInflammationInterferon gamma ReceptorIntestinal DiseasesIntestinal MucosaMiceReceptor, Interferon alpha-betaReceptors, InterferonRotavirusRotavirus InfectionsSTAT1 Transcription FactorCaspasesCytokinesIfnar1 protein, mouseInterferon gamma ReceptorReceptor, Interferon alpha-betaReceptors, InterferonStat1 protein, mouseSTAT1 Transcription Factorcaspase cleavageendotoxingut inflammationinterferon receptorinterferonsnegative feedbackrotavirusSTAT1

Identifiers

PMID31896593
PMCPMC7158711
OpenAlexW2997040649

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.