ArticleProceedings of the National Academy of Sciences of the United States of America2020
The formation of the thumb requires direct modulation of
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Defective HNF1A hinders GLI3 processing favoring duodenal versus pancreatic fate, thus leading to intestinal elongation in vivo.Genes & development · 2026Article
- Evolution of limb and digit identity genes since the tetrapod ancestor.Nature communications · 2026Article
- A pivotal Wnt antagonist role promoting digit joint specification by constraining Wnt activity.Nature communications · 2026Article
- Article
- Single-cell profiling of penta- and tetradactyl mouse limb buds identifies mesenchymal progenitors controlling digit numbers and identities.Nature communications · 2025Article
- Homozygosity for a RareInternational journal of molecular sciences · 2024Article
- TBX3 is essential for establishment of the posterior boundary of anterior genes and upregulation of posterior genes together with HAND2 during the onset of limb bud development.Development (Cambridge, England) · 2024Article
- Role of HOXA1-4 in the development of genetic and malignant diseases.Biomarker research · 2024Review
- Pollicization of index Fingers For Bilateral Hypoplastic Thumbs of Twin Babies: Case Series At Cure Children's Hospital of Ethiopia.International medical case reports journal · 2024Article
- Identification of ancestral gnathostome Gli3 enhancers with activity in mammals.Development, growth & differentiation · 2024Article
- Article
- Digits in a dish: AnFrontiers in cell and developmental biology · 2023Article
- Sonic hedgehog is not a limb morphogen but acts as a trigger to specify all digits in mice.Developmental cell · 2022Article
- Genetic basis for an evolutionary shift from ancestral preaxial to postaxial limb polarity in non-urodele vertebrates.Current biology : CB · 2021Article
- Atavisms in the avian hindlimb and early developmental polarity of the limb.Developmental dynamics : an official publication of the American Association of Anatomists · 2021Article
- Sarcopterygian fin ontogeny elucidates the origin of hands with digits.Science advances · 2020Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
In the tetrapod limb, the digits (fingers or toes) are the elements most subject to morphological diversification in response to functional adaptations. However, despite their functional importance, the mechanisms controlling digit morphology remain poorly understood. Here we have focused on understanding the special morphology of the thumb (digit 1), the acquisition of which was an important adaptation of the human hand. To this end, we have studied the limbs of the
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.