ReviewThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
Revisiting the Stress Concept: Implications for Affective Disorders.
Review in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 313 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
313 citing papers in PubMed, 1 synthesis or guideline pooled it, 617 citations in OpenAlex.
- How childhood adversity affects components of decision making.Neuroscience and biobehavioral reviews · 2025Pooled it
- An open trial of biofeedback for long COVID.Journal of psychosomatic research · 2024Trial
- Long-term metabolic and cardiovascular health benefits from romantic partner touch in older adults.Brain, behavior, & immunity - health · 2026Article
- Reframing stress adaptation as a dynamic system failure along a threat-response continuum: towards a phase-specific, mechanism-driven framework.Molecular psychiatry · 2026Article
- Dihydromyricetin attenuates chronic stress-induced depressive-like phenotypes and modulates Akt/FoxO3a-related signaling in the hippocampus.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Brain mitochondria as key drivers of cognition and behaviour.Nature reviews. Neuroscience · 2026Review
- Protecting Nurses During Pregnancy: Cross-Sectional Study of Workplace Exposures and Modifications.Journal of advanced nursing · 2026Article
- Regular intake of caffeinated but not decaffeinated coffee attenuates behavioral modifications in mice subject to chronic unpredictable stress.Neurobiology of stress · 2026Article
- TrkB promotes the neuronal secretion of soluble Siglec-2 (CD22) to mitigate microglial activation and alleviate depression-like behaviors in male mice.Molecular psychiatry · 2026Article
- Effects of NR3C1 and COMT Genes on Attention-Deficit/Hyperactivity Disorder and Accompanying Aggressiveness: A Cross-Sectional Study in a Clinical Sample.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2026Article
- Article
- A Neurotensin Brake on Exploratory Drive under Persistent Threat.bioRxiv : the preprint server for biology · 2026Article
- Early Life Stress Affects Human Decision Making by Increasing Expectations of Volatility.Developmental science · 2026Article
- Protective Effects ofPharmaceuticals (Basel, Switzerland) · 2026Article
- Prenatal stress, excitatory-inhibitory imbalance, and ADHD risk: a hypothesis-driven perspective on psilocybin-induced neuroplasticity.Translational psychiatry · 2026Review
- Longitudinal Associations Between Victimization and Depressive Mood During the Junior High School Transition: A Latent Growth Model Analysis.Journal of youth and adolescence · 2026Article
- [Psychological distress and cancer: facts and myths in the light of scientific evidence].Magyar onkologia · 2026Review
- Resting HRV predicts cardiac vagal control during stress, not psychological distress.Scientific reports · 2026Article
- Post-traumatic stress disorder.Nature reviews. Disease primers · 2026Review
- Spatial lipidomic and neuron-specific transcriptomic signatures in the nucleus accumbens reveal phospholipid dyshomeostasis in depression-related maladaptations.Translational psychiatry · 2026Article
253 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Over the last 50 years, the concept of stress has evolved significantly, and our understanding of the underlying neurobiology has expanded dramatically. Rather than consider stress biology to be relevant only under unusual and threatening conditions, we conceive of it as an ongoing, adaptive process of assessing the environment, coping with it, and enabling the individual to anticipate and deal with future challenges. Though much remains to be discovered, the fundamental neurocircuitry that underlies these processes has been broadly delineated, key molecular players have been identified, and the impact of this system on neuroplasticity has been well established. More recently, we have come to appreciate the critical interaction between the brain and the rest of the body as it pertains to stress responsiveness. Importantly, this system can become overloaded due to ongoing environmental demands on the individual, be they physical, physiological, or psychosocial. The impact of this overload is deleterious to brain health, and it results in vulnerability to a range of brain disorders, including major depression and cognitive deficits. Thus, stress biology is one of the best understood systems in affective neuroscience and is an ideal target for addressing the pathophysiology of many brain-related diseases. The story we present began with the discovery of glucocorticoid receptors in hippocampus and has extended to other brain regions in both animal models and the human brain with the further discovery of structural and functional adaptive plasticity in response to stressful and other experiences.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.