Evidence map›Paper›PMID 31896498›Full record

ArticleHearing research2020

Evidence for gene-smoking interactions for hearing loss and deafness in Japanese American families.

Jia Y Wan, Christina Cataby, Andrew Liem, Emily Jeffrey, Trina M Norden-Krichmar, Deborah Goodman, Stephanie A Santorico, Karen L Edwards, American Diabetes Association GENNID Study Group

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hearing research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Smoking and alcohol consumption with the risk of 11 common otolaryngological diseases: a bidirectional Mendelian randomization.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Jia Y WanDepartment of Epidemiology, University of California, Irvine, United States.
Christina CatabyDepartment of Population Health and Disease Prevention, University of California, Irvine, United States.
Andrew LiemDepartment of Epidemiology, University of California, Irvine, United States.
Emily JeffreyDepartment of Epidemiology, University of California, Irvine, United States.
Trina M Norden-KrichmarDepartment of Epidemiology, University of California, Irvine, United States.
Deborah GoodmanDepartment of Epidemiology, University of California, Irvine, United States.
Stephanie A SantoricoDepartment of Mathematical and Statistical Sciences, University of Colorado, Denver, United States.
Karen L EdwardsDepartment of Epidemiology, University of California, Irvine, United States; Department of Population Health and Disease Prevention, University of California, Irvine, United States. Electronic address: kedward1@uci.edu.
American Diabetes Association GENNID Study Group
University of California, Irvine · USUniversity of Colorado Denver · USUniversity of Washington · USCedars-Sinai Medical Center · USUniversity of Chicago · USUniversity of Utah · US

Funding

Identifying genes underlying linkage peaks for clusters of CVD risk factorsR01HL113189 · NHLBI · UNIVERSITY OF WASHINGTON · PI EDWARDS, KAREN L · 2012 to 2016
$3.5M
NHLBI NIH HHS R01 HL113189
6 · The paper itself

Abstract

backgroundThis study investigated the relationship between smoking and hearing loss and deafness (HLD) and whether the relationship is modified by genetic variation. Data for these analyses was from the subset of Japanese American families collected as part of the American Diabetes Association Genetics of Non-insulin Dependent Diabetes Mellitus study. Logistic regression with generalized estimating equations assessed the relationship between HLD and smoking. Nonparametric linkage analysis identified genetic regions harboring HLD susceptibility genes and ordered subset analysis was used to identify regions showing evidence for gene-smoking interactions. Genetic variants within these candidate regions were then each tested for interaction with smoking using logistic regression models.

resultsAfter adjusting for age, sex, diabetes status and smoking duration, for each pack of cigarettes smoked per day, risk of HLD increased 4.58 times (odds ratio (OR) = 4.58; 95% Confidence Interval (CI): (1.40,15.03)), and ever smokers were over 5 times more likely than nonsmokers to report HLD (OR = 5.22; 95% CI: (1.24, 22.03)). Suggestive evidence for linkage for HLD was observed in multiple genomic regions (Chromosomes 5p15, 8p23 and 17q21), and additional suggestive regions were identified when considering interactions with smoking status (Chromosomes 7p21, 11q23, 12q32, 15q26, and 20q13) and packs-per-day (Chromosome 8q21).

conclusionsTo our knowledge this was the first report of possible gene-by-smoking interactions in HLD using family data. Additional work, including independent replication, is needed to understand the basis of these findings. HLD are important public health issues and understanding the contributions of genetic and environmental factors may inform public health messages and policies.

Indexed as

Gene-Environment InteractionPolymorphism, Single NucleotideAdaptor Proteins, Signal TransducingAdultAgedAsianCyclic Nucleotide Phosphodiesterases, Type 7DeafnessFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHearingHumansJapanMaleMembrane ProteinsAdaptor Proteins, Signal TransducingCyclic Nucleotide Phosphodiesterases, Type 7Membrane ProteinsPAG1 protein, humanPDE7A protein, humanRepressor ProteinsZBTB10 protein, humanFamilyGene-environment interactionGenome-wide linkageHearing lossLinkageSmoking

Identifiers

PMID31896498
PMCPMC7046312
OpenAlexW2997021798

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.