ArticleThe American journal of bioethics : AJOB2020
Ethics and Collateral Findings in Pragmatic Clinical Trials.
Article in The American journal of bioethics : AJOB, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- A Framework of Institutional Obligations for Pragmatic Clinical Trials.The American journal of bioethics : AJOB · 2026Article
- Monitoring in pragmatic trials lessons from the NIH pragmatic trials collaboratory.Contemporary clinical trials · 2025Article
- Recurring and Emerging Ethical Issues in Pragmatic Clinical Trials.Circulation. Cardiovascular quality and outcomes · 2024Article
- Think Pragmatically: Investigators' Obligations to Patient-Subjects When Research is Embedded in Care.The American journal of bioethics : AJOB · 2023Article
- Do Clinicians Have a Duty to Participate in Pragmatic Clinical Trials?The American journal of bioethics : AJOB · 2023Article
- Patients' Reactions to Letters Communicating Collateral Findings of Pragmatic Clinical Trials: a National Web-Based Survey.Journal of general internal medicine · 2022Article
- Toward Meeting the Obligation of Respect for Persons in Pragmatic Clinical Trials.The Hastings Center report · 2022Article
- Justice and equity in pragmatic clinical trials: Considerations for pain research within integrated health systems.Learning health systems · 2022Article
- Responding to signals of mental and behavioral health risk in pragmatic clinical trials: Ethical obligations in a healthcare ecosystem.Contemporary clinical trials · 2022Article
- Identification and management of pragmatic clinical trial collateral findings: A current understanding and directions for future research.Healthcare (Amsterdam, Netherlands) · 2021Article
- Stakeholder perspectives regarding pragmatic clinical trial collateral findings.Learning health systems · 2021Article
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Authors and funding
6 authors.
Funding
Abstract
Pragmatic clinical trials (PCTs) offer important benefits, such as generating evidence that is suited to inform real-world health care decisions and increasing research efficiency. However, PCTs also present ethical challenges. One such challenge involves the management of information that emerges in a PCT that is unrelated to the primary research question(s), yet may have implications for the individual patients, clinicians, or health care systems from whom or within which research data were collected. We term these findings as ?pragmatic clinical trial collateral findings,? or ?PCT-CFs?. In this article, we explore the ethical considerations associated with the identification, assessment, and management of PCT-CFs, and how these considerations may vary based upon the attributes of a specific PCT. Our purpose is to map the terrain of PCT-CFs to serve as a foundation for future scholarship as well as policy-making and to facilitate careful deliberation about actual cases as they occur in practice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.