ArticlePLoS computational biology2020
Developmental trajectory of Caenorhabditis elegans nervous system governs its structural organization.
Article in PLoS computational biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- Building the connectome of a small brain with a simple stochastic developmental generative model.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Review
- Structural MRI of brain similarity networks.Nature reviews. Neuroscience · 2025Review
- A hierarchy index for networks in the brain reveals a complex entangled organizational structure.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The neuropeptidergic connectome of C. elegans.Neuron · 2023Article
- Early adversity changes the economic conditions of mouse structural brain network organization.Developmental psychobiology · 2023Article
- Dihydroxy-Metabolites of Dihomo-γ-linolenic Acid Drive Ferroptosis-Mediated Neurodegeneration.ACS central science · 2023Article
- Dihydroxy-Metabolites of Dihomo-gamma-linolenic Acid Drive Ferroptosis-Mediated Neurodegeneration.bioRxiv : the preprint server for biology · 2023Article
- Raising the Connectome: The Emergence of Neuronal Activity and Behavior inFrontiers in cellular neuroscience · 2020Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A central problem of neuroscience involves uncovering the principles governing the organization of nervous systems which ensure robustness in brain development. The nematode Caenorhabditis elegans provides us with a model organism for studying this question. In this paper, we focus on the invariant connection structure and spatial arrangement of the neurons comprising the somatic neuronal network of this organism to understand the key developmental constraints underlying its design. We observe that neurons with certain shared characteristics-such as, neural process lengths, birth time cohort, lineage and bilateral symmetry-exhibit a preference for connecting to each other. Recognizing the existence of such homophily and their relative degree of importance in determining connection probability within neurons (for example, in synapses, symmetric pairing is the most dominant factor followed by birth time cohort, process length and lineage) helps in connecting specific neuronal attributes to the topological organization of the network. Further, the functional identities of neurons appear to dictate the temporal hierarchy of their appearance during the course of development. Providing crucial insights into principles that may be common across many organisms, our study shows how the trajectory in the developmental landscape constrains the structural organization of a nervous system.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.