ArticlePloS one2020
Genetic predisposition to celiac disease in Kazakhstan: Potential impact on the clinical practice in Central Asia.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Fecal and Duodenal Microbiota in Pediatric Celiac Disease.Frontiers in pediatrics · 2021Pooled it
- Carrier frequency of HLA-DQB1*02 allele in patients affected with celiac disease: A systematic review assessing the potential rationale of a targeted allelic genotyping as a first-line screening.World journal of gastroenterology · 2020Pooled it
- Berry Powder-Enriched Gluten-Free Extruded Snacks: Nutritional Quality and Antioxidant Potential.Molecules (Basel, Switzerland) · 2026Article
- Total serum IgA levels and HLA-DQB1*02:01 allelic status.Immunologic research · 2024Article
- Compliance and Lifestyle of Children with Celiac Disease in the Iranian Children.Advanced biomedical research · 2024Article
- Thyroid diseases in children and adults with celiac disease: A cross-sectional study.Caspian journal of internal medicine · 2024Article
- Celiac Disease in Uzbek Children: Insights into Disease Prevalence and Clinical Characteristics in Symptomatic Pediatric Patients.Diagnostics (Basel, Switzerland) · 2023Article
- Epidemiological, clinical, and histological presentation of celiac disease in Northwest China.World journal of gastroenterology · 2022Article
- Celiac Disease Revisited.GE Portuguese journal of gastroenterology · 2022Review
- Diagnostic Barriers in Children with Immunodeficiencies in Central Asia: A Case-Based Discussion.Pediatric reports · 2021Article
- Celiac disease in children: A review of the literature.World journal of clinical pediatrics · 2021Review
- Current research status of HLA in immune-related diseases.Immunity, inflammation and disease · 2021Review
- Celiac Disease in Asia beyond the Middle East and Indian subcontinent: Epidemiological burden and diagnostic barriers.World journal of gastroenterology · 2021Article
- Different Clinical Features of Celiac Disease in Children, Adolescents, and Adults; a Cross-sectional Study.Middle East journal of digestive diseases · 2021Article
- HLA major allele group frequencies in a diverse population of the Free State Province, South Africa.Heliyon · 2021Article
- Impact of Serological and Histological Factors on Neurological Manifestations in Children and Adults with Celiac Disease.Pediatric gastroenterology, hepatology & nutrition · 2021Article
- HLA-B*51 allelic and carrier frequency in Kazakhstan: insights into Behçet's disease prevalence in Central Asia.Internal and emergency medicine · 2021Article
- The Role of HLA in the Association between IgA Deficiency and Celiac Disease.Disease markers · 2021Review
- Reliability of the Multiplex CytoBead CeliAK Immunoassay to Assess Anti-tTG IgA for Celiac Disease Screening.Frontiers in medicine · 2021Article
- Celiac Disease as a Cause of Malabsorption: A Clinic-Pathological Series of Five Cases.Case reports in gastroenterologyArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCeliac disease (CD) is a systemic immune-mediated disorder developing in HLA genetically predisposed individuals carrying HLA-DQ2 and/or HLA-DQ8 molecules. Recent evidences supported a predominant importance of HLA-DQB1 locus and, in particular, HLA-DQB1*02 alleles. This diagnosis is poorly considered in Kazakhstan, because of the assumption that CD is not prevalent in this population.
objectiveTo demonstrate that the genetic predisposition to CD in Kazakhstan is not negligible and is actually comparable to Western populations.
methodsThrough the analysis of HLA-DQ genotypes of healthy bone marrow donors from Kazakhstan's national registry, we estimated the HLA-related genetic predisposition to CD in the country.
resultsWe demonstrated that the frequency of CD-related HLA-DQB1 alleles and, as a consequence, of predisposed individuals to CD in Kazakhstan is significant and comparable to countries with the highest disease prevalence.
conclusionConsidering the dietary style in Kazakhstan, including wheat as a staple food, these results provided a preliminary background of knowledge to expect a significant CD prevalence in Kazakhstan and Central Asia by implementing appropriate and cost-effective diagnostic strategies.
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