Evidence map›Paper›PMID 31895645›Full record

ArticleJournal of wildlife diseases2020

SAFETY, IMMUNOGENICITY, AND EFFICACY OF INTRAMUSCULAR AND ORAL DELIVERY OF ERA-G333 RECOMBINANT RABIES VIRUS VACCINE TO BIG BROWN BATS (

Amy T Gilbert, Xianfu Wu, Felix R Jackson, Richard Franka, Gary F McCracken, Charles E Rupprecht

Open access · greenAbstract readClinical Trial, Veterinary
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of wildlife diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Amy T GilbertPoxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, 1600 Clifton Rd. NE, Atlanta, Georgia 30333, USA.
Xianfu WuPoxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, 1600 Clifton Rd. NE, Atlanta, Georgia 30333, USA.
Felix R JacksonPoxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, 1600 Clifton Rd. NE, Atlanta, Georgia 30333, USA.
Richard FrankaCenter for Global Health, Global Immunization Division, Centers for Disease Control and Prevention, 1600 Clifton Rd. NE, Atlanta, Georgia 30333, USA.
Gary F McCrackenDepartment of Ecology and Evolutionary Biology, University of Tennessee, 1416 Circle Dr., Knoxville, Tennessee 37996, USA.
Charles E RupprechtLYSSA LLC, 309 Pirkle Ferry Rd., Suite D300, Cumming, Georgia 30040, USA.
Centers for Disease Control and Prevention · USCenter for Global Health · USUniversity of Tennessee at Knoxville · US

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

Attenuated strains of rabies virus (RABV) have been used for oral vaccination of wild carnivores in Europe and North America. However, some RABV vaccines caused clinical rabies in target animals. To improve the safety of attenuated RABV as an oral vaccine for field use, strategies using selection of escape mutants under monoclonal antibody neutralization pressure and reverse genetics-defined mutations have been used. We tested the safety, immunogenicity, and efficacy of one RABV construct, ERA-g333, developed with reverse genetics by intramuscular (IM) or oral (PO) routes in big brown bats (

Indexed as

ChiropteraAdministration, OralAnimalsAntibodies, NeutralizingInjections, IntramuscularRabiesRabies VaccinesVaccinationVaccines, SyntheticAntibodies, NeutralizingRabies VaccinesVaccines, SyntheticBatEptesicus fuscusERArabiesreverse geneticsvaccination

Identifiers

PMID31895645
PMCPMC11307205
OpenAlexW2997021004

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.