Evidence map›Paper›PMID 31895257›Full record

Trial reportDermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]2020

Differential Analgesia From Vibratory Stimulation During Local Injection of Anesthetic: A Randomized Clinical Trial.

Rashek Kazi, Panayiota Govas, Rachel M Slaugenhaupt, Bryan T Carroll

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Impact of Anesthetic Cream and Vibration on Injection Pain in Lymphedema.Plastic and reconstructive surgery. Global open · 2026
    Article
  4. Article
  5. Article
  6. Olfactory Sensitivity Is Related to Erectile Function in Adult Males.Frontiers in cell and developmental biology · 2020
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Rashek KaziDepartment of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Panayiota GovasDepartment of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Rachel M SlaugenhauptDepartment of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Bryan T CarrollDepartment of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
University of Pittsburgh · US

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR001857 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2016 to 2025
$129.3M
NCATS NIH HHS UL1 TR001857
6 · The paper itself

Abstract

backgroundInadequate pain reduction during anesthetic injection is a significant medical and surgical problem. Vibratory distraction reduces this pain; however, there are minimal data identifying those who respond best.

objectiveTo quantify analgesia from vibration before anesthetic injection. MATERIALS AND

methodsIn this partially blinded, single-institution trial, adult participants were randomized to intervention (vibratory anesthetic device, VAD ON) or placebo (VAD OFF). Pain was assessed using the 11-point numeric rating scale (NRS). Relative reduction in NRS between VAD OFF and ON was used to identify minimum clinically important and substantially clinically important difference in pain.

resultsOne hundred one tested sites from 87 subjects were assessed. Sixty-three percent were men with a median age of 66 years. From univariate analysis, males, subjects aged <60, and head and neck (HN) treated subjects had a significant reduction in NRS (p < .05). Multivariate analysis identified NRS reductions in females <60 (p = .012), males ≥70 (p = .002), females and males treated on HN (p = .048 and p = .035, respectively), and males ≥70 treated on HN (p = .012). Substantially clinically important difference (≥57% NRS reduction) included subjects <60, females <70, HN treatment aged 60 to 69, males ≥70, and females treated on HN.

conclusionVibratory anesthetic device reduces pain during anesthetic injection, primarily for HN treatments and older male subjects.

Indexed as

AdultAgedAged, 80 and overAnalgesiaAnesthetics, LocalFemaleHumansInjections, SubcutaneousMaleMiddle AgedMohs SurgeryPain MeasurementProcedural PainTreatment OutcomeVibrationAnesthetics, Local

Identifiers

PMID31895257
PMCPMC8388110
OpenAlexW2998486947

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.