Evidence map›Paper›PMID 31895179›Full record

ArticleMenopause (New York, N.Y.)2020

Relationship between BRSK1 rs12611091 variant and age at natural menopause based on physical activity.

Chun-Lang Su, Yi-Ling Tsai, Oswald Ndi Nfor, Wen-Hsiu Liu, Chien Chang Ho, Chia-Chi Lung, Yi-Tien Lin, Lee Wang, Yung-Po Liaw

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Menopause (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 82% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Chun-Lang SuDepartment of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung City, Taiwan.
Yi-Ling TsaiDepartment of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung City, Taiwan.
Oswald Ndi NforDepartment of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung City, Taiwan.
Wen-Hsiu LiuDepartment of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung City, Taiwan.
Chien Chang HoDepartment of Physical Education, Fu Jen Catholic University, New Taipei City, Taiwan.
Chia-Chi LungDepartment of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung City, Taiwan.
Yi-Tien LinDepartment of Business Administration, College of Management, Fu Jen Catholic University, New Taipei City, Taiwan.
Lee WangDepartment of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung City, Taiwan.
Yung-Po LiawDepartment of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung City, Taiwan.
Chung Shan Medical University · TWFu Jen Catholic University · TWChung Shan Medical University Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe rs12611091 variant in the BR serine/threonine kinase 1 gene is one of the variants previously associated with age at natural menopause. So far, this variant has not been replicated in Taiwanese women. The purpose of this study was to determine the association between rs12611091 and age at natural menopause based on physical activity.

methodsA total of 1,758 women were eligible for analysis whose information about menopause was collected from the Taiwan Biobank. Multiple linear regression analysis was used for analysis.

resultsThe mean age (standard deviation) at natural menopause was 50.82 (3.59) years. Of the eligible participants, 56.94% were rs12611091 CC carriers, 36.69% were TC carriers, and 6.37% were TT carriers. Compared to CC carriers, TC and TT carriers were associated with early menopause (β = -0.42, P = 0.02 and -0.87, P = 0.01, respectively). There was a significant interaction between rs12611091 and physical activity (P for interaction = 0.02). Compared to rs12611091 CC carriers, TC and TT carriers who were physically inactive were significantly associated with earlier menopause (β = -0.88, P < 0.01 and -1.25, P = 0.02, respectively).

conclusionWe demonstrated that rs12611091 variant was associated with age at natural menopause especially among inactive women in Taiwan. That is, women with TC and TT genotypes who were physically inactive were significantly associated with earlier natural menopause compared to those with CC genotype.

Indexed as

ExerciseIntracellular Signaling Peptides and ProteinsProtein Serine-Threonine KinasesAge FactorsFemaleHumansMenopauseMiddle AgedTaiwanBRSK1 protein, humanIntracellular Signaling Peptides and ProteinsProtein Serine-Threonine Kinases

Identifiers

PMID31895179
PMCPMC7147414
OpenAlexW2998049418

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.