Evidence map›Paper›PMID 31894843›Full record

Trial reportBioscience reports2020

The effect of wuling capsule on depression in Type 2 diabetic patients.

Huanping Wang, Huizhen Chen, Yang Gao, Shengju Wang, Xian Wang, Xiaomei Tang, Wei Fang, Xiaoyan Shi, Jia Yao, Qiu Chen

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Bioscience reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 20 citations in OpenAlex.

  1. Ethanol extract ofIranian journal of basic medical sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Huanping WangDepartment of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, China.
Huizhen ChenDepartment of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, China.
Yang GaoDepartment of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, China.
Shengju WangDepartment of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, China.
Xian WangDepartment of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, China.
Xiaomei TangDepartment of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, China.
Wei FangDepartment of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, China.
Xiaoyan ShiDepartment of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, China.
Jia YaoDepartment of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, China.
Qiu ChenDepartment of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, China.
Chengdu University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveDepression is a common complication in Type 2 diabetes mellitus (T2DM); however, it has long been underrecognized and undertreated. In the present study, we aimed to evaluate the clinical effects of Wuling capsule, a compound traditional Chinese herbal medicine, on T2DM complicated with depression.

method66 patients were enrolled and randomly divided into Wuling capsule treatment group and placebo group, and finally 64 cases finished the present study. The levels of FPG, 2hPG, HbAlc, TNF-α, IL-6, SOD, MDA, Cor, ACTH, HOMA-β, HOMA-IR and ISI of patients were evaluated and compared. The HAMD scale for patients were recorded.

resultAfter 12-week treatment, the HAMD scale decreased in both groups, and was lower in Wuling capsule group. The level of FPG in Wuling capsule group was significantly lower than in placebo group; however, no obvious changes of 2hPG and HbA1c were found. The levels of IL-6 and TNF-α were significantly decreased in both groups, and more obviously in Wuling capsule group. The level of SOD was increased while the level of MDA was decreased significantly in both groups, and the changes were more obviously in Wuling capsule group. The levels of Cor and ACTH were significantly decreased in both groups; however, there was no statistically significance between the two groups. Besides, the comparisons of HOMA-β, HOMA-IR and ISI between the two groups were not statistically significant.

conclusionOur results suggested that Wuling capsule ameliorated the depression in patients with T2DM, and also improved the state of inflammation and oxidative stress state. These results also strongly indicated the ability of clinical transformation of Wuling capsule in patients with T2DM in the future.

Indexed as

Adrenal GlandsAdrenocorticotropic HormoneAffectAntidepressive AgentsAnti-Inflammatory AgentsAntioxidantsBiomarkersChinaDepressionDiabetes Mellitus, Type 2Double-Blind MethodDrugs, Chinese HerbalFemaleHumansHydrocortisoneHypothalamo-Hypophyseal SystemAdrenocorticotropic HormoneAntidepressive AgentsAnti-Inflammatory AgentsAntioxidantsBiomarkersDrugs, Chinese HerbalHydrocortisoneInflammation MediatorswulingDepressionInflammatory factorsOxidative stressType 2 diabetes mellitusWuling capsule

Identifiers

PMID31894843
PMCPMC7029151
OpenAlexW3005742743

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.