Evidence map›Paper›PMID 31894501›Full record

ReviewMycopathologia2020

The Mycobiome in Health and Disease: Emerging Concepts, Methodologies and Challenges.

Pei Yee Tiew, Micheál Mac Aogain, Nur A'tikah Binte Mohamed Ali, Kai Xian Thng, Karlyn Goh, Kenny J X Lau, Sanjay H Chotirmall

Abstract readReview
In one paragraph

Review in Mycopathologia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. The Gut Mycobiome for Precision Medicine.Journal of fungi (Basel, Switzerland) · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. The porcine skin microbiome exhibits broad fungal antagonism.Fungal genetics and biology : FG & B · 2024
    Article
  17. Infection and the microbiome in bronchiectasis.European respiratory review : an official journal of the European Respiratory Society · 2024
    Review
  18. Article
  19. A comprehensive guide to assess gut mycobiome and its role in pathogenesis and treatment of inflammatory bowel disease.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2024
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pei Yee TiewLee Kong Chian School of Medicine, Nanyang Technological University, 11 Mandalay Road, Singapore, 308232, Singapore.
Micheál Mac AogainLee Kong Chian School of Medicine, Nanyang Technological University, 11 Mandalay Road, Singapore, 308232, Singapore.
Nur A'tikah Binte Mohamed AliLee Kong Chian School of Medicine, Nanyang Technological University, 11 Mandalay Road, Singapore, 308232, Singapore.
Kai Xian ThngLee Kong Chian School of Medicine, Nanyang Technological University, 11 Mandalay Road, Singapore, 308232, Singapore.
Karlyn GohSchool of Biological Sciences, Nanyang Technological University, Singapore, Singapore.
Kenny J X LauLee Kong Chian School of Medicine, Nanyang Technological University, 11 Mandalay Road, Singapore, 308232, Singapore.
Sanjay H ChotirmallLee Kong Chian School of Medicine, Nanyang Technological University, 11 Mandalay Road, Singapore, 308232, Singapore. schotirmall@ntu.edu.sg.ORCID http://orcid.org/0000-0003-0417-7607

Funding

ALTERNATIVE PATHWAYS OF T CELL ACTIVATIONK08AR002017 · NIAMS · VANDERBILT UNIVERSITY · PI BYRD, VICTOR M · 1998 to 2002
$348k
Nanyang Technological University NIM/03/2018Nanyang Technological University (SG) ARISE/2017/6National Medical Research Council Singapore MOH-000141National Medical Research Council Singapore NMRC/Fellowship/0049/2017Singapore Ministry of Education 2016-T1-001-050
6 · The paper itself

Abstract

Fungal disease is an increasingly recognised global clinical challenge associated with high mortality. Early diagnosis of fungal infection remains problematic due to the poor sensitivity and specificity of current diagnostic modalities. Advances in sequencing technologies hold promise in addressing these shortcomings and for improved fungal detection and identification. To translate such emerging approaches into mainstream clinical care will require refinement of current sequencing and analytical platforms, ensuring standardisation and consistency through robust clinical benchmarking and its validation across a range of patient populations. In this state-of-the-art review, we discuss current diagnostic and therapeutic challenges associated with fungal disease and provide key examples where the application of sequencing technologies has potential diagnostic application in assessing the human 'mycobiome'. We assess how ready access to fungal sequencing may be exploited in broadening our insight into host-fungal interaction, providing scope for clinical diagnostics and the translation of emerging mycobiome research into clinical practice.

Indexed as

FungiMycobiomeMycosesComputational BiologyHigh-Throughput Nucleotide SequencingHost Microbial InteractionsHumansMetagenomicsPathology, MolecularBioinformaticsClinicalITS sequencingMetagenomicsMycobiome

Identifiers

PMID31894501
PMCPMC7223441

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.